Dex对腹腔镜下结直肠癌术后早期POCD的影响

Clinical feasibility and effect analysis of laparoscopic staging of early endometrial carcinoma

目的:探讨腹腔镜结直肠癌手术患者应用右美托咪啶(Dex)对患者术后早期认知功能障碍(POCD)的影响。方法:选取2014年6月—2015年12月拟进行腹腔镜结直肠癌手术120例作为研究对象,采用随机数字表法分为空白组(等量生理盐水)和Dex高剂量组、中剂量组、低剂量组,分别于气管插管后给予Dex 0.8、0.5、0.2μg/(kg·h),每组各30例,手术结束前40 min停止输注,对比两组POCD的发生情况。结果:各组患者的手术时间、出血量差异均无统计学意义(P>0.05)。高剂量组、中剂量组的恢复自主呼吸的时间、睁眼时间均显著长于空白组和低剂量组(P<0.05);高剂量组的拔出气管导管时间均显著长于空白组和低剂量组(P<0.05)。术后1、3 d,高剂量组、中剂量组的MMSE评分均显著高于空白组和低剂量组(P<0.05)。术后1、3 d,高剂量组、中剂量组的POCD发生率显著低于空白组和低剂量组(P<0.05)。结论:腹腔镜结直肠癌手术患者气管插管后给予Dex 0.8、0.5μg/(kg·h)输注,有利于降低患者发生POCD发生率。

Objective： To investigate the clinical effect and feasibility of taparoscopic staging of endometrial carcinoma. Methods： Selected June 2014 to 2015 December gastrointestinal tract, plans of laparoscopic surgery for colorectal cancer in 120 cases as the object of study, using random number table were divided into control group （saline）, DEX high dose group, middle dose group, low dose group, respectively after tracheal intubation given DEX 0.8, 0.5, 0.2 μg （kg·h） with 30 cases in each, the operation end of 40 min before infusion was stopped, compared two groups of POCD.Results There was no sig ifference in the operation time and blo groups （P〉0.05）. The time neous breathing and the time of longer in the high dose grouj Idle dose group than in the blank （P〈0.05）. The time of endot atheterlzation in high dose that in blank group and low p 〈0.05）. The MMSE scon middle dose group were signhigher than those of the blank erative （P〈0,05）. The incidence of PO ostoperative1,3d, high dose! significantly lower,than that in bl roup and low dose group（P〈C 8, 0,5 μg/（kg· h） infusion after tracheal intubation in patients with laparo rgery is beneficial to reduce the incidence of POCD.