胰升糖素肽-1及其相关药物对2型糖尿病血管并发症影响的研究进展

Advances in the study of GLP-1 and its related drugs on vascular complications in type 2 diabetes

胰升糖素肽-1(GLP-1)是主要由肠道L细胞分泌的一种胃肠道激素,其对2型糖尿病患者具有多重影响,促进胰岛素分泌、改善β细胞功能、降低胰高血糖素分泌、延缓胃排空、增强饱腹感和减少食欲,给2型糖尿病患者治疗带来新的契机。GLP-1及其相关药物对2型糖尿病血管并发症具有保护作用,加强这方面的研究可能会为2型糖尿病及其相关的微血管、大血管病变的治疗带来新的希望。现综述GLP-1及其相关药物对2型糖尿病血管并发症的影响研究进展。

Glucagon like peptide 1（GLP-1）is a gastrointestinal hormone mainly secreted by intestinal L cells,which has multiple effects on diabetes,promotes insulin secretion,improvesβcell function,reduces glucagon secretion, delays gas-tric emptying,enhances satiety and reduces appetite,and bring new opportunities for the treatment of type 2 diabetes.Recent studies have found that GLP1 and related drugs have a protective effect on the Type 2 diabetic vascular complications, strengthening research in this area may bring new hope for clinical treatments of type 2 diabetes and related microvascular/ma-crovascular lesion.