卡培他滨联合沙利度胺对晚期结直肠癌节拍化疗的效果

Metronomic chemotherapy effect of Capecitabine combined with Thalidomide in the chemotherapy of advanced colorectal cance

目的探讨卡培他滨联合沙利度胺对晚期结直肠癌节拍化疗的临床疗效。方法选取2016年2月~2017年3月我院收治的56例确诊为晚期结直肠癌的患者作为研究对象,按照随机数字表法将其分为联合组(n=30)与化疗组(n=26)。联合组患者采用卡培他滨联合沙利度胺进行治疗,化疗组患者第1天静脉注射奥沙利铂,第2~5天静脉注射亚叶酸钙,以20 d为1个周期。比较两组患者的化疗效果、治疗效果及不良反应发生情况。结果联合组患者的疾病控制率为76.67%,化疗组为53.85%,两组患者的疾病控制率比较,差异有统计学意义(P<0.05)。联合组患者的治疗总有效率为80.00%,明显高于治疗组的34.62%,差异有统计学意义(P<0.05)。联合组患者的不良反应总发生率(33.33%)明显低于化疗组(92.31%),差异有统计学意义(P<0.05)。结论卡培他滨联合沙利度胺对晚期结直肠癌节拍化疗效果显著,安全性高,不良反应率低,值得向临床推广应用。

Objective To investigate the clinical effect of Capecitabine combined with Thalidomide in the metronomic chemotherapy of advanced colorectal cancer.Methods From February 2016 to March 2016,56 patients who diagnosed with advanced colorectal cancer treated in our hospital were selected as the research objects,and they were divided into the combination group （n=30） and chemotherapy group （n=26） according to random number table method.The combination group were treated with Capecitabine combined with Thalidomide.In the chemotherapy group,Oxaliplatin was injected intravenously on the first day and Leucovorin was injected intravenous from second to fifth days,and 20 days for one cycle.The effects of chemotherapy,therapeutic effect and adverse reactions were compared between the two groups.Resuits The disease control rate of the patients in the combination group was 76.67%,and in the chemotherapy group was 53.85%,the control rate of the disease was compared between the two groups,and the difference was statistically signifi- cant （P〈0.05）.The total effective rate of treatment was 80.O0%,which was significantly higher than 34.62% in the chemother- apy group,and the difference was statistically significant （P〈0.05）.The total incidence of adverse reactions （33.33%） in the combination group was significantly lower than that in the chemotherapy group （92.31%）,and the difference was sta- tistically significant （P〈0.05）.Conclusion Capecitabine combined Thalidomide in the treatment of advanced colorectal cancer has remarkable efficacy,high safety and low adverse reaction rate,so it is worth using in clinical.