氯吡格雷用于冠心病治疗的效果以及不良反应分析

Analysis Effect of Clopidogrel on Treatment of Coronary Heart Disease and Adverse Reactions

目的观察分析氯吡格雷治疗冠心病患者的临床效果以及安全性,为临床上合理的选择用药提供依据。方法选择我院2015年4月—2017年3月收治的冠心病患者110例作为本次研究的观察对象,随机分为对照组和研究组,每组55例。对照组采用阿司匹林进行治疗,研究组采用氯吡格雷进行治疗,比较两组的临床疗效,并观察治疗期间两组患者的不良反应发生情况。结果研究组患者的临床总有效率为96.36%,高于对照组的81.82%,差异有统计学意义(P<0.05);治疗期间,两组患者均无严重的不良反应发生。研究组不良反应发生率为5.45%,低于对照组的18.18%,差异有统计学意义(P<0.05)。结论与阿司匹林比较,氯吡格雷治疗冠心病患者的临床疗效更加显著,安全性更好。

Objective To observe and analyze the clinical effect and safety of clopidogrel in the treatment of coronary heart disease （CHD）, and provide the basis for the rational selection of drugs in the clinic. Methods 110 patients with coronary heart disease admitted from April 2015 to March 2017 in our hospital were selected as the observation subjects, they were randomly divided into control group and research group, 55 cases in each group. The control group was treated with aspirin, and the study group was treated with clopidogrel. During the period of treatment, the clinical effects of the two groups were compared and the adverse reactions in the two groups were observed. Results The total clinical effective rate of the patients in the study group was 96.36%, which was higher than that of the control group 81.82%, and the difference was statistically significant （P 〈 0.05）. During the treatment, there was no serious adverse reaction in the two groups. The incidence of adverse reactions in the study group was 5.45%, which was lower than that of the control group 18.18%, and the difference was statistically significant （P 〈 0.05）. Conclusion Compared with aspirin, clopidogrel is more effective and safer in patients with coronary heart disease.