普萘洛尔对PCI指数的影响及与EVB相关性研究

Study on the Effect of Propranolol on PCI Index and its Correlation With EVB

目的探讨普萘洛尔对肝硬化门静脉充血指数(PCI)的影响以及与食管胃静脉曲张出血(EVB)之间的相关性。方法选取35例肝硬化EVB患者,测定PCI,Child A、B级患者给予普萘洛尔治疗,治疗后3个月复测PCI,观察6个月内再出血情况,根据是否再出血分为不出血组及再出血组。结果 Child A、B、C级患者PCI水平比较,差异有统计学意义,P<0.05;PCI与Child积分成正相关;Child A、B级患者普萘洛尔治疗前后PCI比较,差异有统计学意义,P<0.05;治疗后不出血组和再出血组PCI水平比较,差异有统计学意义,P<0.05。结论 PCI可作为判断肝硬化EVB有价值的指标,对临床治疗评估提供参考。

Objective To investigate the effect of propranolol on portal venous congestion index （PCI） and the correlation with esophageal and gastric variceal bleeding （EVB）. Methods The level of PIC in 35 patients with cirrhosis EVB were measured, Child A and B patients were treated with propranolol. After 3 months of treatment, PCI was remeasured, rebleeding was observed within 6 months. The rebleeding group were divided into non bleeding group and rebleeding group according to whether or not it was rebleeding. Results The difference of PCI level in patients with Child A, B and C was statistically significant, P 〈 0.05; The PCI was positively correlated with the Child integral. Child A, B patients with propranolol before and after the treatment of PCI, the difference was statistically significant, P 〈 0.05; The difference of PCI level between the non bleeding group and the rebieeding group after treatment was statistically significant, P 〈 0.05. Conclusion PCI can be used as a valuable index to judge the EVB of liver cirrhosis, and provide reference for the evaluation of clinical treatment.