两种药物联用对重症胰腺炎患者肠黏膜屏障功能的影响

Effects of Two Drugs on Intestinal Mucosal Barrier Function in Patients With Severe Pancreatitis

目的探讨埃索美拉唑、生长抑素结合治疗重症胰腺炎患者的效果及对肠道黏膜屏障功能的影响。方法将82例重症胰腺炎患者随机分为2组(n=41),对照组采用常规疗法,联合组加用埃索美拉唑、生长抑素,对比治疗效果。结果联合组治疗后的腹内高压水平低于对照组,PE、D-乳酸、UAMY、DAO水平均显著低于对照组(P<0.05)。联合组患者的症状缓解时间、肠道功能恢复时间、住院时间均短于对照组(P<0.05)。联合组的治疗总有效率95.12%,高于对照组73.17%(P<0.05)。结论埃索美拉唑联合生长抑素治疗重症胰腺炎能够有效减轻腹内高压,改善肠道黏膜的屏障功能,临床疗效显著。

Objective To explore the effect of the combination of esomeprazole and somatostatin in the treatment of severe pancreatitis and the influence on intestinal mucosal barrier function. Methods 82 cases of severe pancreatitis were randomly divided into two groups （n=41）. The control group was treated with conventional therapy, and the experimental group was treated with esomeprazole and somatostatin, the treatment effect between two groups were compared. Results The levels of PE, D-lactic acid, UAMY and DAO in the experimental group were significantly lower than control group （P〈0.05）. The symptom remission time, the intestinal function recovery time and the hospitalization time in the experimental group were significantly shorter than control group （P〈0.05）. The total effective rate was 95.12% in the experimental group, which was significantly higher than the control group 73.17% （P〈0.05）.Conclnsion The combination of esomeprazole and somatostatin in the treatment of severe pancreatitis can effectively reduce the intraperitoneal high pressure and improve the intestinal mucosal barrier function, which has a significant clinical efficacy.