黄龙止咳方联合西药治疗小儿咳嗽变异性哮喘的临床效果

Clinical Observation on Huanglong Zhike Fang Combined with Western Medicine in Treating Infantile Cough Variant Asthma

目的:观察黄龙止咳方联合西药治疗小儿咳嗽变异性哮喘的临床疗效并探讨其作用的机制。方法:选择咳嗽变异性哮喘患儿80例,按随机数字表法分为观察组和对照组,每组40例,观察组予黄龙止咳方联合沙丁胺醇气雾剂和孟鲁司特钠咀嚼片治疗,对照组采用西医常规治疗。监测治疗前后患者咳嗽、咽痒、痰量的症状积分、血清中Ig E的水平,比较2组治疗疗效,记录治疗过程中的不良反应及随访复发情况。结果:观察组和对照组总有效率分别为92.31%、75.00%,观察组疗效明显优于对照组(P<0.05);2组患者治疗后咳嗽积分、痰量积分、咽痒积分较治疗前均降低(P<0.05),且观察组患者的各症状积分明显低于对照组(P<0.05);2组患者治疗后Ig E的水平较治疗前均降低(P<0.05),且观察组明显低于对照组(P<0.05);2组患者在治疗过程中均未出现严重不良反应;2组患者治疗结束后随访半年,观察组未复发率为43.59%,对照组未复发率为15%,观察组复发率明显低于对照组(P<0.05)。结论:黄龙止咳方联合西药治疗能够有效的改善患者的咳嗽、咽痒、痰多症状,并能显著降低患者血清中Ig E的水平。

Objective： To observe the clinical effects of Huanglong Zhike Fang combined with Western medicine on infantile cough variant asthma（ CVA）. Methods： A total of 80 cases of children with CVA were selected and divided into treatment group and control group according to random number table,with 40 cases in each. The treatment group received the treatment of Huanglong Zhike Fang combined with Salbutamol aerosol and Montelukast Soudium chewable tablets. The control group received routine Western medicine treatment. The change of cough symptom scores,pharyngeal itching symptom scores,sputum volume scores and Ig E were monitored before and after treatment. After treatment,the therapeutic effects of the 2 groups were compared. The adverse events during treatment and the patients with recurrence were recorded. Results： 1） The total effective rate of the treatment group and the control group were 92. 31% and 75%,and the treatment group was significant better than the control group（ P 0. 05）;2） Compared with before treatment,cough symptom scores,pharyngeal itching symptom scores and sputum volume scores of 2 groups were decreased,and the treatment group was significant better than the control group（ P 0. 05）; 3） Compared with before treatment,the levels of Ig E of 2 groups was decreased,and the treatment group was significant better than the control group（ P 0. 05）; 4） In the course of treatment,no serious adverse reactions occurred in both groups; 5） Patients of 2 groups were followed up for 6 months after treatment,and the unrecurrence rate in the treatment group was 43. 59% and 15% in control group.The unrecurrence rate in the treatment group was significantly lower than that in the control group（ P 0. 05）. Conclusion： Huanglong Zhike Fang combined with western medicine in treating infantile CVA could improve the symptoms of cough and itching symptoms,reduce sputum volume,and significantly decrease the levels of Ig E.