小青龙汤加减治疗慢性阻塞性肺病急性加重的临床效果

Clinical Study on the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Modified Xiao Qinglong Decoction

目的:探讨小青龙汤加减治疗慢性阻塞性肺病急性加重(AECOPD)患者的临床效果。方法:选取2013年2月至2016年2月我院收治的AECOPD患者180例,根据随机信封抽签原则分为观察组与对照组各90例,对照组给予西医常规治疗方案,观察组在对照组治疗的基础上加服小青龙汤剂加减治疗,2组都以10 d为1个疗程,治疗观察3个疗程。结果:治疗后观察组与对照组的总有效率分别为95.6%和84.4%,观察组的总有效率明显高于对照组(P<0.05)。观察组与对照组治疗后的CD4+细胞分别为(36.34±7.83)%和(33.66±9.82)%,都明显高于治疗前的(30.33±6.49)%和(30.49±5.33)%(P<0.05),且观察组明显高于对照组(P<0.05)。治疗后观察组与对照组的FEV1与FEV1/FVC值都高于治疗前(P<0.05),同时治疗后观察组的FEV1与FEV1/FVC值明显也都明显高于对照组(P<0.05)。观察组与对照组治疗后的血清IL-6和TNF-α值都明显低于治疗前(P<0.05),同时治疗后观察组的血清IL-6和TNF-α值明显低于对照组(P<0.05)。结论:小青龙汤加减治疗AECOPD患者可通过改善呼吸肌功能、调节机体免疫能力、调节炎性反应因子的释放等多个方面发挥综合效应,提高治疗效果。

Objective： To investigate the clinical effects of modified Xiao Qinglong Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods： From February 2013 to February 2016,a total of 180 AECOPD patients in our hospital were selected and divided into observation group and control group with 90 cases in each. The control group was treated with conventional western medicine,and the observation group was given Xiao Qinglong Decoction based on the treatment of the control group. With 10 d as a a course of treatment in the two groups,to observe for 3 courses. Results： The total effective rate of the observation group and the control group were 95. 6% and 84. 4% respectively. The total effective rate of the observation group was significantly higher than that of the control group（ P 0. 05）. In the observation group and control group after treatment,the contents of CD4＋cells were 36. 34 ± 7. 83% and 33. 66 ± 9. 82%,respectively that were significantly higher than before treatment of 30. 33 ± 6. 49% and 30. 49 ± 5. 33%（ P 0. 05）,and the observation group was significantly higher than that of the control group（ P 0. 05）. After treatment,the FEV1 and FEV1/FVC values in the observation group and the control group were higher than before treatment（ P 0. 05）,while the FEV1 and FEV1/FVC values of the observation group were significantly higher than those in the control group（ P 0. 05）. The serum IL-6 and TNF-α values in the observation group and control group after treatment were significantly lower than before treatment（ P 0. 05）,while the serum IL-6 and TNF-α values in the observation group after treatment were significantly lower than the control group（ P 0. 05）. Conclusion： Xiao Qinglong Decoction in the treatment of patients with AECOPD can take comprehensive effect by improving respiratory muscle function,regulating the body＇ s immune function,regulating the release of inflammatory factors,and it can improve the treatment effect.