胃溃灵汤结合针灸治疗消化性溃疡的疗效及对血清免疫功能蛋白和血清炎性反应因子的影响

Curative Effects of Weikuiling Decoction Combined with Acupuncture and Moxibustion on Peptic Ulcer and Influence on the Level of Serum Immune Function Protein and Serum Inflammatory Factors

目的:分析胃溃灵汤结合针灸治疗消化性溃疡的疗效及对血清免疫功能蛋白水平变化、血清炎性反应因子水平的影响。方法:选取2015年5月至2016年6月接收的消化性溃疡患者共70例,并依据就医顺序,随机分成2组,每组35例。对照组给予胃溃灵汤;观察组在对照组的基础上加用针灸治疗。对2组患者临床疗效、治疗前后中医候证积分、免疫球蛋白水平、血清炎性反应因子水平进行测定。结果:观察组总有效率94.29%,对照组总有效率71.43%,2组比较差异有统计学意义(P<0.05);观察组治疗后疲倦乏力、胃脘痛、反酸嗳气、纳差便溏4项中医症候评分明显低于对照组(P<0.05);观察组治疗后免疫球蛋白Ig G、Ig A、Ig M水平显著高于对照组(P<0.05);观察组治疗后IL-6、TNF-α、TGF-β1水平明显低于对照组。结论:针灸结合胃溃灵汤治疗消化性溃疡具有良好效果,并能有效改善患者免疫功能蛋白及血清炎性反应因子水平。

Objective： To analyze the curative effects of Weikuiling decoction combined with acupuncture and moxibustion on peptic ulcer and influence on the levels of serum immune function protein and serum inflammatory factors. Methods： A total of 70 patients with peptic ulcer in our hospital from May 2015 to June 2016 were selected and randomly divided into 2 groups according to the order of treatment,with 35 cases in each group. The control group was given Weikuiling decoction,while the observation group was treated with acupuncture on the basis of the control group. The clinical efficacy,TCM syndrome score,immunoglobulin levels,serum levels of inflammatory factors of 2 groups before and after treatment were measured. Results： The total efficiency of the observation group was 94. 29% and 71. 43% in the control group,The difference between the 2 groups was statistically significant（ P 0. 05）; TCM symptom scores of fatigue,epigastric pain,belching,acid regurgitation,anorexia and loose stools after treatment in observation group were significantly lower than the control group（ P 0. 05）; the levels of immunoglobulin Ig G,Ig A,Ig M in the observation group after treatment were significantly higher than that of the control group（ P 0. 05）; The levels of IL-6,TNF-alpha,TGF-beta 1 after treatment in observation group were significantly lower than the control group. Conclusion： Acupuncture combined with Weikuiling decoction has good effects in treating peptic ulcer,and can effectively improve the levels of immune function protein and serum inflammatory factors in patients with peptic ulcer.