针刺结合普罗布考对缺血性脑血管病伴颈动脉斑块患者神经功能恢复及炎性因子的影响

Effects of Acupuncture Combined with Probucol on Recovery of Nerve Function and Inflammatory Factors of Patients with Ischemic Cerebrovascular Disease with Carotid Plaque

目的:探讨针刺结合普罗布考对缺血性脑血管病伴颈动脉斑块患者神经功能恢复及炎性因子的影响。方法:选取2014年4月至2017年4月陆军总医院附属八一脑科医院收治的缺血性脑血管病伴颈动脉斑块患者125例,随机分为观察组(n=63)与对照组(n=62),对照组采用普罗布考治疗,观察组在对照组基础上结合针刺治疗,2组治疗周期均为50d。比较2组患者临床疗效;检测治疗前后2组患者斑块状况;比较2组患者治疗前后神经功能恢复情况及炎性因子水平。结果:治疗后,观察组的总有效率96.83%显著高于对照组的85.48%(P<0.01);与治疗前比较,治疗后2组患者IMT、斑块面积、斑块数量均下降,且观察组低于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组患者血清Hb A1c、血浆Hcy水平、NHISS评分及血清hs-CRP、IL-6、IL-18水平均下降,且观察组低于对照组(P<0.01)。结论:针刺结合普罗布考治疗缺血性脑血管病伴颈动脉斑块可抑制斑块发展,降低神经功能缺损程度及血清炎性因子水平,临床疗效可靠。

Objective： To explore the effects of acupuncture combined with probucol on recovery of nerve function and inflammatory factors of patients with ischemic cerebrovascular disease with carotid plaque. Methods： A total of 125 cases of patients with ischemic cerebrovascular disease with carotid plaque from April 2013 to April 2017 were selected and randomly divided into observation group（ n = 63） and control group（ n = 62）. The control group was treated with probucol,and the observation group was treated with acupuncture on the basis of control group. Both groups were treated for 50 days. The clinical efficacy of 2 groups was compared. The plaque condition of 2 groups before and after treatment was detected. The recovery of nerve function and the levels of inflammatory factors of 2 groups before and after treatment were compared. Results： The total effective rate of observation group reached up to 96. 83% after treatment,which was higher than that 85. 48% of control group（ P 0. 01）; Compared with before treatment,the IMT,plaque area,number of plaques of 2 groups decreased after treatment,and observation group was lower than control group（ P 0. 05 or P 0. 01）; Compared with before treatment,the levels of serum Hb A1 c,plasma Hcy,NHISS scores and the levels of serum hs-CRP,IL-6,IL-18 of 2 groups decreased after treatment,and observation group was lower than control group（ P 0. 01）. Conclusion： Acupuncture combined with probucol in the treatment of ischemic cerebrovascular disease with carotid plaque can inhibit the development of plaque,reduce the degree of neurological deficits and the levels of serum inflammatory factor,and the clinical efficacy is remarkable.