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乙型肝炎病毒核糖核酸的检测及其与抗病毒治疗相关性的研究进展

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摘要 HBV是一种威胁全球人类健康的病毒,也是导致肝硬化及肝细胞癌的主要病因。据估计,全球约2.4亿人为慢性HBV感染者,我国约有9300万人。HBV是一种独特的DNA病毒,其的复制需要通过前基因组RNA(pgRNA)来完成。目前用于治疗CHB的抗病毒药物主要有干扰素和核苷(酸)类似物,它们通过直接或间接抑制病毒复制来发挥抗病毒作用。HBVpgRNA的生成不受核苷(酸)类似物的盲棒影响。却能被干扰素抑制.
出处 《中华传染病杂志》 CSCD 北大核心 2017年第10期638-640,共3页 Chinese Journal of Infectious Diseases
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