排石颗粒配合盐酸坦洛新对输尿管软镜治疗大于2.0 cm肾结石疗效分析

Efficacy of Paishi Granule Combined with Tamsuloside Hydrochloride in Treatment of 2.0 cm Kidney Stone

目的 :探讨排石颗粒配合盐酸坦洛新对电子输尿管软镜治疗大于2.0 cm肾结石的临床疗效。方法 :将2015年3月—2017年3月江苏大学附属医院90例应用输尿管软镜治疗直径大于2.0 cm的肾结石患者随机分为实验组和对照组,每组各45例。实验组配合中药排石颗粒及盐酸坦洛新缓释片,对照组仅配合盐酸坦洛新。服药后每周复查1次,疗程4周或至排石干净。分别于第2周、第4周进行疗效判定。观察指标为结石清除率、肾绞痛发生概率、结石排出时间以及膀胱过度活动症(OABSS)评分。结果 :(1)实验组结石清除率为97.8%,对照组清除率为86.7%,差异具有统计学意义(P<0.05);(2)治疗组结石排出时间为(5.6±1.67)d,对照组排出时间为(12.7±2.63)d,差异具备统计学意义(P<0.05);(3)实验组肾绞痛发生率为8.9%,对照组发生率为24.4%,差异具备统计学意义(P<0.05);(4)实验组OABSS评分为(5.3±1.19)分,对照组OABSS评分为(11.2±2.67)分,差异具备统计学意义(P<0.05)。结论 :排石颗粒配合盐酸坦洛新对电子输尿管软镜治疗大于2.0 cm结石患者具有结石清除率高、肾绞痛发生概率小、结石排出时间短以及并发症少的治疗优势。

Objective ：To discuss on the clinical efficacy of Paishi Granule combined with tamsulosin hydrochloride in the treatment of more than 2.0 cm kidney stones with electron ureteroscopy.Methods ：90 patients with renal tubules with diameter greater than 2.0 cm were randomly divided into experimental group and control group（n=90）.The number of patients are from March 2008—March 2017 from affiliated hospital of Jiangsu university.Each group contains 45 cases.The experimental group combined with Chinese medicine row of stone particles and tamsulosin hydrochloride sustained release tablets,the control group was only treated with tamsulosin hydrochloride.After taking a review once a week,the course of treatment or to the row of stone clean.The efficacy was determined at week 2 and week 4,respectively.Observed indicators for stone clearance,renal colic occurrence probability,stone discharge time and over-bladder activity（OABSS）score.Results ：（1）The clearance rate of the experimental group was 97.8%,the control group was 86.7%,the difference was statistically significant（P〈0.05）.（2）（5.6±1.67）days in the treatment group and（12.7±2.63）days in the control group,the difference was statistically significant（P〈0.05）.（3）The incidence of renal colic was 8.9% in the experimental group and 24.4% in the control group,the difference was statistically significant（P〈0.05）.（4） The score of OABSS was（5.3±1.19）points in the experimental group and（11.2±2.67）points in the control group,the difference was statistically significant（P〈0.05）.Conclusion ：Paishi Granule combined with tannopium hydrochloride for electronic ureteral soft mirror treatment of patients greater than 2.0 cm stones with high stone clearance rate,renal colic occurrence probability is small,shorter stone discharge time and less complications of treatment advantages.