肠道营养素感知系统和血糖控制关系研究进展

Advances in the Relationship between Intestinal Nutrient Perception System and Blood Glucose Control

在肠道内分泌细胞中存在特定营养感知系统,能够感知肠道内容物,该系统被激活后能够释放胃肠激素。在这些所释放的肽类激素当中,抑胃肽和胰高血糖素样肽-1在维持人体葡萄糖动态平衡中起着独特的作用,在调节代谢的同时,使得β细胞发挥其适宜的功能。该文重点阐述肠道感知营养的过程及其在糖尿病的发生中所起的作用。

Nutrient-specific sensor systems in enteroendocrine cells detect intestinal contents and cause gut hormone release upon activation.Among these peptide hormones,the incretins glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 are of particular interest by their role in glucose homeostasis,metabolic control and for proper β-cell function.This review focuses on intestinal nutrientsensing processes and their role in health and disease.