冷诱导蛋白CIRP和RBM3生物学功能研究进展

Research progresses in biological functions of cold-inducible proteins CIRP and RBM3

在低温刺激下,CIRP和RBM3两种RNA结合蛋白表达上调.这两种蛋白在分子和细胞水平发挥的作用有其相似点但又各有其独特性.CIRP在细胞内对机体具有保护作用,可是一旦释放到细胞外进入血液循环便会诱发机体严重的炎症反应,加重脓毒症患者的症状并影响预后.而RBM3无论是在细胞内还是释放到细胞外始终对机体具有保护作用.现如今,用ELISA试剂盒定量检测外周血中CIRP的分泌水平是可行的,这提供了一种新的诊断脓毒症的标准.另外,在多种肿瘤细胞中均能检测到CIRP以及RBM3的高表达.研究发现,在化疗患者的肿瘤组织中,RBM3的高表达有利于提高化疗患者的生存率,而CIRP的高表达则会降低患者的生存率.本文主要对CIRP以及RBM3的分子结构、表达特点以及其在感染、肿瘤等病理生理状态下的功能及相关的调节机制进行综述.

The transcription of cold-inducible RNA-binding protein （CIRP） and RNA-binding motif protein 3 （RBM3） are upregulated under the low temperature. These two kinds of pro- teins have many similarities in the role of molecular and cellular levels, but each has its uniqueness. If CIRP was within the cells, it has a protective effect, but once released into the extracellular environment and enter into blood circulation, it will induce severe inflammation reaction, and then increase the symptoms and affect prognosis of patients with sepsis. However, RBM3 always has a protective effect both within and outsides of cells. Nowadays, quantitative detection of CIRP secretion level in peripheral blood is feasible by using ELISA kit, which has created a feasible new standard diagnosis of sepsis. In addition, high levels of CIRP and RBM3 expression have been analyzed in varies of human tumor. Studies indicated that the expression of RBM3 in the tumor tissues was positively associated with the survival of tumor patients, while CIRP expression was inversely linked to the survival of tumor patients. In this review, the molecular structure, expression features of CIRP and RBM3 and functions and regulatory mechanisms of CIRP and RBM3 in the physiological and pathological processes of inflammation and cancer development were summarized.