白细胞介素36在慢性炎性疾病中作用的研究进展

The research progress of interleukin-36 in the chronic inflammatory disease

白细胞介素（interleukin，IL）36是一种新型促炎因子，可由皮肤、滑膜、结肠黏膜等多种类型的细胞产生，IL-36可诱导炎症介质的产生并促进树突状细胞的成熟。IL-36可被中性粒细胞来源的酶强有力激活，通过与一种异质二聚体受体结合组成IL-36R亚基和IL-1RAcP激活MAPK和NF．KB／AP-1等重要信号通路，在人类先固有免疫和适应性性免疫中发挥着重要作用，研究发现，IL-36对慢性炎症的发生发展及诊断和预后具有重要的参考价值，有望成为慢性炎性疾病基因诊疗的新靶点。

Interleukin （IL）-36 is a new type of pro-inflammatory factor, and various types of cells in skin, synovial membrane and colonic mucosa can induce them. IL-36 can promoted the produced inflammatory medium the maturation of dendritic cells, and can be activated by the enzyme of neutrophil. IL-36 can activated important signaling pathways such as MAPK and NF-KB/AP-1 by binding to a heterodimeric recptor consisting of the IL-36 receptor（IL-36R） subunit and the IL-1R accessory protein（IL-1RAcP） ,and plays an important role in the human inherent immunity and adaptive immunity. The research found IL-36 has important reference value for the occurrence, development, diagnosis and prognosis of chronic inflammation, and is epected to be a new target for gene diagnosis and treatment of chronic inflammatory diseases.