摘要
A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded under mild reaction conditions, exhibited good functional group tolerance with a broad scope of substrate and excellent regi- oselectivity in good to excellent yields.
A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded under mild reaction conditions, exhibited good functional group tolerance with a broad scope of substrate and excellent regi- oselectivity in good to excellent yields.
基金
Financial support from National Natural Science Foundation of China （Nos. 21162012 and 21362014） and Key Laboratory of Functional Small Organic Mol-ecule, Ministry of Education, Jiangxi Normal University （No. KLFS-KF-201407） is gratefully acknowledged.
