同型半胱氨酸和超敏C反应蛋白联合测定对冠心病患者发病机制及预后判断的影响

Effect of joint determination of homocysteine and high sensitive C-reactive protein on judgment of pathogenesis and prognosis in coronary heart disease patients

目的分析同型半胱氨酸和超敏C反应蛋白联合测定对冠心病患者发病机制及预后判断的影响。方法选取2014年9月—2016年5月在信阳市中心医院进行冠状动脉造影检查的冠心病患者70例作为观察组,另选取同期进行健康体检人员70例作为对照组,采用循环酶法检测同型半胱氨酸水平,采用免疫比浊法检测超敏C反应蛋白水平,对比两组同型半胱氨酸及超敏C反应蛋白水平、观察组中不同病情间同型半胱氨酸及超敏C反应蛋白水平。结果对照组同型半胱氨酸及超敏C反应蛋白水平均低于观察组,差异有统计学意义(P<0.05);UAP及AMI患者同型半胱氨酸及超敏C反应蛋白水平均高于SAP,差异有统计学意义(P<0.05)。结论同型半胱氨酸和超敏C反应蛋白可作为判断冠心病患者病情严重程度的重要指标,且反映了冠状动脉的病变程度,为临床尽早诊治提供了强有力的依据,对延缓患者的病情、改善预后具有重要的意义。

Objective To analyze the effect of joint determination of homoeysteine （HCY） and high sensitive C -- reac- tive protein （Hs - CRP） on the judgment of pathogenesis and prognosis in coronary heart disease （CHI）） patients. Methods Totally 70 CHD patients with coronary angiography in our hospital from September 2014 to May 2016 were selected as observation group, and 70 healthy controls in our hospital were selected as control group at the same time. The HCY levels were assessed by enzymatic cycling assay, and Hs - CRP levels were assessed by immunoturbidimetry. The HCY and Hs - CRP levels of two groups, HCY and Hs - CRP levels in different eonditions of observation group were compared. Results The HCY and Hs - CRP levels of control group were lower than those of observation group （P 〈 0. 05 ） ; The HCY and Hs -CRP levels of UAP and AMI patients were higher than those of SAP patients （P 〈0. 05 ）. Conclusion HCY and Hs - CRP can be taken as important indexes of judging the disease severity of CHD patients, and they can reflect severity of coronary artery disease, provide strong basis for early clinical treatment, delay the pro- gress of disease and improve prognosis.