老年性高血脂患者服药依从性及其对外周血ROS水平的影响

Effects of medication compliance and ROS level of peripheral blood in elderly patients with hyperlipidemia

目的:探讨老年性高血脂患者服药依从性及其对外周血ROS水平的影响。方法:采用分层整群随机抽样法选择2014-01~2015-12因高血脂就诊于我院心内科的老年患者428例。使用Morisky问卷以及社会支持评定量表(SSRS)对入组患者的服药依从性及影响因素进行调查和统计学分析。筛选我院体检中心>60岁的健康体检者168名为健康对照组,使用ELISA法检测入组患者及健康对照者血清ROS水平。结果:老年性高血脂患者的服药依从性一般与服药种类和患病年限呈负相关(P<0.05,P<0.01);与非医保患者相比,医保患者的服药依从性明显较高(P<0.05);此外,经济条件较好的患者以及城镇患者的服药依从性明显高于经济条件较差及农村患者(P<0.05,P<0.01)。多因素分析表明,服药依从性一般与服药种类和患病年限呈负相关(Y=-1.28X+4.389,R2=4.27,P<0.01)。高血脂患者血清ROS水平明显高于健康对照组,使用减压疗法治疗后,血清ROS水平明显降低,差异具有统计学意义(P<0.05),但血清ROS水平仍高于对照组。结论:高血脂患者血清ROS水平比血脂正常者明显增高,减压治疗后,可明显改善高血脂患者血清ROS水平,且服药依从性增加。随着患病年限加长,服药种类增多,老年性高血脂患者的服药依从性逐渐减弱。通过有效措施提高医疗保险覆盖率,可以提高经济条件较差的老年性高血脂患者的服药依从性。

Objective：To investigate the effects of medication compliance and ROS level of peripheral blood in elderly patients with hyperlipidemia.Methods：A total of 428 elderly patients with hyperlipidemia from January 2014 to December 2015 were selected.The compliance and influencing factors of the patients were analyzed with Morisky and social support rating scale（SSRS）.And 168 healthy elderly without hyperlipidemia were selected as control group,the level of serum ROS was detected with ELISA.Results：The medication compliance in elderly patients with hyperlipidemia were negatively correlated with the types of medicine and time of disease（P〈0.05,P〈0.01）.Compared with non medicare patients,the compliance was higher than medicare patients（P 〈0.05）.In addition,medication compliance in patients with better economic conditions and urban were significantly higher than those with poor economic conditions and non urban（P〈0.05,P〈0.01）.Multiple factor analysis showed that medication compliance was negatively correlated with the types of medication and time of disease（Y=-1.28 X＋4.389,R2=4.27,P〈0.01）.Serum ROS levels in patients with hyperlipidemia were significantly higher than those in control group,after decompression therapy,serum ROS was significantly reduced,and the difference was statistically significant（P〈0.05）,but serum levels of ROS was still higher than that in the control group.Conclusion：The medication compliance of elderly patients with hyperlipidemia is gradually decreased with the increase time of the disease and the types of medication.Through effective measures to improve the coverage rate of medical insurance can increase medication compliance of poor elderly patients with hyperlipidemia.