噻托溴铵联合舒利迭治疗重度以上慢阻肺的疗效观察

Efficacy of Tiotropium Combined with Seretide in Patients with Severe COPD

目的探讨分析噻托溴铵联合舒利迭治疗重度以上慢阻肺的临床效果。方法回顾性分析2016年1月-2017年1月于我院接受治疗的50例重度以上慢阻肺稳定期患者,并随机分成两组。25例患者予以噻托溴铵联合舒利迭治疗,为观察组;另25例患者予以单纯舒利迭治疗,为对照组。比较两组患者治疗前后MMRC评分、6分钟步行试验(6MWT)、肺功能指标。结果两组患者治疗后MMRC评分、6MWT、肺功能指标较治疗前显著改善,且观察组患者改善情况更加明显,比较差异具有统计学意义(P<0.05)。结论对重度以上慢阻肺患者稳定期采用噻托溴铵联合舒利迭治疗,能显著改善患者相关症状及肺功能。

Objective To analyze the efficacy of Tiotropium combined with Seretide in patients with severe COPD. Methods 50 patients with severe COPD were selected from January 2016 to January 2017 and were divided into observation group and control group. They were given Tiotropium and Seretide, Seretide alone. MMRC, 6 MWT and pulmonary function of two groups were compared. Results MMRC, 6 MWT and pulmonary function of patients in observation were better than control group, with significant difference（P〈0.05）. Conclusion Tiotropium combined with Seretide can improved the MMRC, 6 MWT and pulmonary function of patients with severe COPD.