西藏地区上消化道疾病与幽门螺杆菌感染相关性研究

Correlation between Upper Gastrointestinal Diseases and Helicobacter Pylori Infection in Tibet

目的了解西藏地区上消化道疾病患者幽门螺杆菌(Helicobacter pylori,HP)感染状况,为防治上消化道疾病提供临床依据。方法回顾性分析4332例长期居住在西藏地区的上消化道疾病患者的病例资料,通过13C尿素呼气试验(13C—UBT)及电子胃镜常规检查,检测不同疾病HP感染状况,分析性别、年龄、疾病与HP感染的相关性。结果 4332例患者中,HP总感染率61.9%;其中男性为63.7%(1475/2316),女性为59.9%(1208/2016),差异有统计学意义(χ~2=6.487,P=0.011);各年龄组HP感染率≤20岁为69.6%(149/214),21~30岁为72.6%(684/942),31~40岁为67.0%(780/1165),41~50岁为57.9%(563/973),51~60岁为52.1%(353/677),>60岁为42.7%(154/361),不同年龄组HP感染率不同,差异有统计学意义(χ~2=12.044,P=0.034);临床常见的上消化道疾病中,以复合性溃疡HP阳性率最高(89.4%),慢性萎缩性胃炎HP感染率最低(45.7%),差异有统计学意义(P<0.05)。结论上消化道疾病与HP感染关系密切,且不同性别、年龄的患者疾病感染率有差异。

Objective To investigate the helicobacter pylori（HP） infection in cases with upper gastrointestinal diseases in Tibet. Methods A retrospective analysis was made to the clinical data of 4332 cases with upper gastrointestinal diseases,who were long-term residents in Tibet; 13C urea breath test（13C-UBT） and routine examination of electronic gastroscope were applied in detecting the HP infection in different diseases; the correlation of gender,age and diseases with HP infection was analyzed. Results The total infective rate of HP in the 4332 cases was 61.9%： 63.7%male（ 1475/2316） and 59.9% female（ 1208/2016）,the difference was of statistical significance（ χ^2= 6.487,P = 0.011）; the infective rate in each age group was 69.6%（ under 20 years old,149/214）,72.6%（ from 21 to 30 years old,684/942）,67.0%（ from 31 to 40 years old,780/1165）,57.9%（ from 41 to 50 years old,563/973）,52.1%（ from 51 to 60 years old,353/677） and 42.7%（ over 60 years old,154/361） respectively,the difference was of statistical significance（ χ^2= 12.044,P = 0.034）; among the common upper gastrointestinal diseases,combined peptic ulcer was of the highest infective rate of HP（89.4 %） while chronic atrophic gastritis was of the lowest rate（45.7 %）,the difference was of statistical significance（ P〈0.05）. Conclusions Upper gastrointestinal diseases are closely correlated with HP infection and cases of different gender,age and disease have different infective rates.