microRNA在慢性乙型肝炎肝纤维化中的诊断价值

Value of microRNAs in diagnosis of chronic hepatitis B-related liver fibrosis

寻找能够准确识别慢性乙型肝炎(CHB)肝纤维化的血清标志物十分重要。归纳了在CHB肝纤维化过程中存在表达差异的microRNA(miRNA),分析表明随着肝纤维化发展,血清miR-33a、miR-185、miR-222等表达量升高,而血清miR-122、miR-29、miR-27b等表达量下降。发现血清miR-185、miR-122等miRNA单独或联合其他指标在诊断CHB肝纤维化中已具有一定的临床应用价值。认为应进一步加大对存在差异表达的具有诊断CHB肝纤维化价值的血清miRNA的研究。

It is very important to find suitable serum markers which can accurately identify chronic hepatitis B（ CHB）-related liver fibrosis. This article summarizes the differentially expressed serum microRNAs（ miRNAs） in the process of CHB-related liver fibrosis. The analysis shows that with the development of liver fibrosis,there are increases in the serum levels of miR-33 a,miR-185,and miR-222 and reductions in the serum levels of miR-122,miR-29,and miR-27 b. It has been found that miRNAs such as miR-185 and miR-122 measured alone or in combination with other indices have a certain clinical value in the diagnosis of CHB-related liver fibrosis. It is pointed out that further research should be conducted for differentially expressed serum miRNAs which have a certain value in the diagnosis of CHB-related liver fibrosis.