非酒精性脂肪性肝病的治疗进展

Advances in the treatment of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)已成为世界第一大肝病,患病率在持续上升,且作为代谢综合征的组分成为多种严重心脑血管疾病的危险因素。因NAFLD发病机制复杂、共同或相互作用,迄今仍缺乏公认、有效的治疗方法。近年来,越来越多的研究揭示了NAFLD的更多发病机制及相应的治疗前景。介绍了NAFLD的治疗进展,包括生活方式干预、药物治疗、中西医结合模式治疗以及减肥手术,其中药物治疗方面,包括临床常用药物以及最新的处于临床第二、三期试验中的药物及其作用评估。

Nonalcoholic fatty liver disease（ NAFLD） has become a major liver disease in the world and its prevalence rate continues to increase. As a component of metabolic syndrome,it has become a risk factor for many serious cerebrovascular and cardiovascular diseases.Due to the complex pathogenesis of NAFLD or the combined/mutual effect of pathogenic factors,there are still no widely accepted effective therapies. In recent years,more and more studies have revealed new pathogeneses of NAFLD and the prospects of corresponding treatment.This article introduces the recent advances in the treatment of NAFLD,including lifestyle intervention,drug therapy,integrated traditional Chinese and Western medicine therapy,and bariatric surgery. In the aspect of drug therapy,this article introduces the drugs commonly used in clinical practice and new drugs in phase II and III clinical trials and their therapeutic effects.