非酒精性脂肪性肝病的潜在新疗法

Potential therapeies for nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是全世界最常见的慢性肝脏疾病,其与肥胖、高脂血症、胰岛素抵抗和2型糖尿病相关。脂质的沉积、胰岛素抵抗、炎症反应均可导致NAFLD的形成,但是具体形成机制尚不明确。随着对NAFLD发病机制的深入研究,巨噬细胞、氧化应激、肠道菌群种类等均影响NAFLD的形成,相应的调控巨噬细胞的极化、抗氧化剂类胡萝卜素及抗肿瘤坏死因子的使用可以阻止或者延缓NAFLD的进程。综述了NAFLD潜在新疗法的研究进展。

Nonalcoholic fatty liver disease（ NAFLD） is one of the most common chronic liver diseases in the world,and it is associated with obesity,hyperlipidemia,insulin resistance,and type 2 diabetes. Lipid deposition,insulin resistance,and inflammatory response may induce NAFLD,but detailed mechanism remains unknown. In-depth studies on the pathogenesis of NAFLD have found that macrophage,oxidative stress,and gut microbiota have certain influence on the pathogenesis of NAFLD,and regulation of macrophage polarization and application of carotenoids and anti-tumor necrosis factor may prevent or delay the progression of NAFLD. This article reviews the research advances in potential therapies for NAFLD.