皮肤软组织感染患儿金黄色葡萄球菌的耐药性分析

Analysis of drug resistance of Staphylococcus aureus in children with skin and soft tissue infections

目的探讨皮肤软组织感染(SSTIs)患儿中金黄色葡萄球菌(SAU)的耐药性。方法选取2015年1月-2016年12月医院收治的SSTIs患儿922例,记录患儿临床资料并采集脓液标本后培养SAU,乳胶凝集试验鉴定菌株。结果 SSTIs患儿感染位置以颈部感染为主162例占17.6%,手指甲沟的SAU分离率最高,占66.1%;1~12月的患儿SAU分离概率最高,为30.3%,且不同年龄组患儿分离出SAU的概率差异有统计学意义(P<0.05);SAU对红霉素、青霉素、克林霉素以及甲氧苄啶的耐药率较高,均>55%,对阿莫西林敏感,未发现万古霉素耐药菌株。结论 SAU诱发的SSTIs多发于婴幼儿,其中脓肿较常见,对红霉素、青霉素、克林霉素以及甲氧苄啶的耐药率比较高,但是对β-内酰胺类的抗菌药物及阿莫西林敏感性较为理想,在治疗过程中医务人员应当引起重视。

OBJECTIVE To investigate the drug resistance of Staphylococcus aureus（SAU）in children with skin and soft tissue infections（SSTIs）.METHODS A total of 922 children with SSTIs in our hospital from Jan.2015 to Dec.2016 were enrolled.The SAU was recorded after the general data were collected and the samples were collected.The samples were identified by latex agglutination test.RESULTS Main infection stie of children with SSTIs infection was neck infection,which was 162 cases,accounting for 17.6%.The highest isolation rate for SAU was66.1%in finger nail neck.The highest proportion of SAU separation was 30.3%in children of 1~12 months,and the children of different age groups had significant differences in the proportion of isolated SAU（P〈0.05）.SAU had high resistant rates to erythromycin,penicillin,clindamycin and trimethoprim,which were over 55%,were susceptible to amoxicillin,and no vancomycin resistant strains were found.CONCLUSIONSAU induced SSTIs is more common in infants,the abscess is common,the pathogens have high resistant rates to erythromycin,penicillin,clindamycin and trimethoprim,but are sensitive to beta-lactam antibiotics and amoxicillin,so medical staff should pay attention to them in the process of treatment.