血清尿酸水平与良性阵发性位置性眩晕的相关性探讨

The correlation between serum uric acid level and benign paroxysmal position vertigo

目的探讨血清尿酸(UA)水平与良性阵发性位置性眩晕(BPPV)的相关性。方法收集2016-05-2017-04徐州医科大学附属医院神经内科入院110例BPPV患者,另选取50例年龄、性别相匹配的为对照组,分别测定尿酸、空腹血糖、胆固醇、低密度脂蛋白、同型半胱氨酸、血压,对高血压、糖尿病、吸烟等心脑血管疾病相关的危险因素进行分析。结果 2组尿酸、胆固醇水平比较差异有统计学意义(P<0.05),组间年龄、性别、吸烟、饮酒、空腹血糖、血压、低密度脂蛋白、同型半胱氨酸以及高血压、糖尿病病史比较差异均无统计学意义(P>0.05)。Logistic多因素分析发现低水平低密度脂蛋白OR(95%CI)2.329(1.243~4.364)、低水平同型半胱氨酸OR(95%CI)1.084(1.005~1.169)是BPPV的危险因素,未发现UA是BPPV的危险因素(OR=0.995)。结论基于本人群的研究提示BPPV患者血UA水平显著高于对照组,但未发现UA是BPPV的危险因素。

Objective To explore the possible relationship between uric acid and benign paroxysmal positional vertigo. Methods Total of 110 patients with benign paroxysmal positional vertigo from the Department of Neurology, Affiliated Hospital of Xuzhou Medical College, were recruited. A cohort of unrelated 60 healthy controls was recruited. Venous blood was collected from peripheral vein of each participant. Then biochemical analyses, homocysteine, blood pressure, were analyzed between two groups. All risk factors of heart and cerebral vascular diseases, such as smoking,drinking, history of high blood pressure, diabetes were analyzed. Results Difference were statistically significant in the distributions of cholesterol and serum uric acid between BPPV group and control group （P〈0. 05）. There was no statistical difference in the distribution of age, sex, smoking, drinking, fasting blood glucose, blood pressure, low density lipoprotein cholesterol, homocysteine, history of high blood pressure, diabetes between BPPV group and control group （P〈0. 05）. Logistic regression analysis found that low level of low density lipoprotein cholesterol,low level of homocysteine was a risk factor for BPPV,with the odds rato of 2. 329 （1. 243±4. 364）, 1. 084 （1. 005± 1. 169）. However, the level of uric acid was not the risk factor for the occurrence of BPPV with the odds ratio of 0. 995 （0. 990±1. 000）. Conclusion Based on this study, the level of serum uric acid with BPPV was significantly higher than that of control group, but the serum uric acid is not an independent risk factor for BPPV. Further studies are needed to clarify the risk factors of BPPV.