青年隐源性卒中和卵圆孔未闭的相关性研究

The correlation study between young cryptogenic stroke and patent foramen ovale

目的探讨卵圆孔未闭(PFO)与青年隐源性卒中(CS)的相关性。方法择取60例青年CS患者为研究组,选取同期60例非CS患者为对照组。2组均给予常规实验室检查、颅脑多普勒超声检查(TCD)、头颅MRI检查,并进行TCD发泡试验(c-TCD),比较2组生化检验、TCD发泡试验、TCD检查结果。结果研究组PFO发生率(53.33%)显著高于对照组(10%),差异有统计学意义(P<0.05)。组间饮酒吸烟史、糖尿病、高血压、冠心病发生率以及血脂指标比较差异无统计学意义(P>0.05)。结论 CS患者多发生PFO,临床可针对此危险因素进一步诊断,必要时可组织会诊,采用介入治疗。

Objective To explore the correlation between young cryptogenic stroke （CS） and patent foramen ovale （PFO）. Methods From January 2012 to January 2014,60 young patients with cryptogenic stroke in our hospital were selected as the study group and 60 cases of non-youth CS patients were selected as the control group. Two groups were treated with routine laboratory tests, brain Doppler ultrasound （TCD）, MRI examination and TCD foaming test （c-TCD）. The result of biochemical tests foam experiments and TCD were compared between the two groups. Results In the PFO,the study group had a significantly higher PFO （53.33% ） than that of the control group （10 %）. The two groups showed similar rate of alcohol intake history, diabetes, hypertension,coronary disease and blood lipid index （P 〉0.05）. Conclusion CS is frequently occurred in patients with PFO, doctors should consider it in the clinical diagnosis and ask for consultation if the interventional therapy is needed.