摘要
外泌体(exosomes)是由多种活细胞主动向外分泌的大小均一的囊泡样小体,可携带蛋白质、脂质、核酸等生物活性成分,参与细胞通讯、细胞迁移、免疫反应和血管新生等诸多过程。寄生虫来源的外泌体不仅可以在虫体间传递毒力因子、抗药基因和分化因子,而且可以调控宿主的基因表达和免疫反应,参与寄生虫致病过程。关于寄生虫外泌体的研究已成为一个新兴领域,这为寄生虫病的诊断和治疗带来新的契机。
Exosomes secreted by various types of living cells are homogenous membrane vesicles that contain biologicalproteins, lipids and nucleotide, and involved in mutiple processes such as cell-cell communication, cell migration, immuneresponse and angiogenesis. Parasite-derived exosomes are able to transfer virulence factors, drug-resistance genes anddifferentiation factors between parasites, modulate the gene expression and immune response of the host, as well as causedisease. Parasite-derived exosomes-related studies have brought up a booming research field, which will shed light on thenovel diagnosis methods and therapy strategies of parasitosis.
出处
《中国热带医学》
CAS
2017年第12期1267-1272,共6页
China Tropical Medicine
