氨氯地平联合替米沙坦治疗高血压合并阻塞性睡眠呼吸暂停低通气综合征

Treatment of hypertension with obstructive sleep apnea hypopnea syndrome by Amlodipine combined with Telmisartan

目的观察氨氯地平联合替米沙坦治疗高血压合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)临床效果。方法选取我院2016年1月20日~2017年1月20日收治的80例高血压合并OSAHS患者,随机分为对照组(采用氨氯地平联合倍他乐克治疗)和观察组(采取氨氯地平联合替米沙坦治疗),各40例,将两组患者临床疗效、临床指标及不良反应发生情况进行比较。结果观察组治疗总有效率97.50%,与对照组相比具有高度的差异性(P<0.05)。观察组患者收缩压、舒张压、心率及呼吸暂停低通气指数均优于对照组(P<0.05)。观察组高血压合并阻塞性睡眠呼吸暂停低通气综合征患者不良反应发生率2.50%,优于对照组(P<0.05)。结论采用氨氯地平联合替米沙坦治疗高血压合并OSAHS患者,具有十分显著的效果,且安全性较高,能够有效改善患者血压水平,值得研究。

Objective To observe the effect of amlodipine combined with telmisartan in the treatment of hypertensive patients with obstructive sleep apnea hypopnea syndrome（OSAHS）. Methods 80 patients who had hypertension and OSAHS in our hospital from January 20,2016 to January 20,2017,were divided randomly and averagely into control group（treated with amlodipine and betaloc）and observation group（treated with amlodipine and telmisartan）. The clinical curative effect,clinical indicators and the incidence of adverse reactions of the two groups were compared. Results The total effective rate was 97.50% in observation group. Compared with the control group,the difference was significant（P〈0.05）. The systolic blood pressure,diastolic blood pressure,heart rate and AHI of the observation group were significantly better than those in the control group（P〈0.05）. The incidence of adverse reactions in the observation group was 2.50% which is better than that in the control group（P〈0.05）. Conclusion Amlodipine combined with telmisartan can treat hypertension of patients who also had OSAHS effectively. The prescription is safe and can effectively improve the patient＇s blood pressure level. So it is worthy of study.