摘要
变应性鼻炎(AR)是鼻黏膜上发生的由Ig E介导的I型变态反应性疾病,临床症状主要包括鼻塞、流鼻涕、打喷嚏和鼻痒。转化生长因子-β1(transforming growth factor-β1,TGF-β1)是一种参与细胞的生长、发育和分化,组织修复和纤维化,及调节炎性免疫应答的多功能细胞因子。目前对于TGF-β1的研究主要集中的支气管哮喘的气道结构重塑方面,对于其在AR中的作用尚存在争议。本文就近几年来相关学者关于TGF-β1在AR的发病机制及组织重塑中的相关研究进展进行总结,以期能够为学者研究AR提供相关的理论依据和治疗的新靶点。
Allergic rhinitis （AR） is an Ig E-mediated type I allergic disease that occurs in the nasal mucosa. The clinical symptoms are characterized primarily by nasal congestion, runny nose, sneezing and/or nasal itching. The Transforming growth factor-beta 1 （TGF-β1） is a multifunctional cytokine, which can play an important part in cell develop and transformation, tissue repair and fibrosis, and regulating inflammatory immune responses. At present, the study of transforming growth factor betal mainly focuses on the airway remodeling of bronchial asthma, there is still some controversy in the related effects of allergic rhinitis. In this paper, we summarized the relevant research progress of TGF-β1 in the pathogenesis and tissue remodeling of allergic rhinitis in recent years, which can provide a theoretical basis and a new target for treatment for the later study of allergic rhinitis by scholars.
出处
《中国医学文摘（耳鼻咽喉科学）》
2017年第6期379-381,378,共4页
Chinese Medical Digest(Otorhinolaryngology)
