脐带间充质干细胞在造血干细胞移植中作用的研究进展

Research Advance on Role of Umbilical Cord Mesenchymal Stem Cell in Hematopoietic Stem Cells Transplantation——Review

造血干细胞移植(HSCT)是治疗恶性血液病的重要方法,移植后造血恢复及移植物抗宿主病(GVHD)的预防及治疗是影响移植成功的关键。脐带间充质干细胞(hUC-MSC)可以改善造血微环境,促进造血干细胞归巢,促进造血恢复,支持造血。此外,hUC-MSC对多种免疫细胞都具有免疫调节功能,可以避免和减轻宿主免疫应答,对治疗GVHD有一定疗效。本文就hUC-MSC在HSCT中的作用的研究作一综述。

Hematopoietic stem cell transplantation is an important method for the treatment of hematological malignancies. The hematopoietic recovery after transplantation, graft-versus-host disease（ GVHD） prevention and treatment are the key to affect transplant success. Umbilical cord mesenchymal stem cells（ hUC-MSC） can improve the hematopoietic microenvironment, promote hematopoietic stem cell homing and hematopoietic recovery, support hematopoiesis. In aduition,the hUC-MSC have immune function for a variety of immune cells,can avoid and alleviate the host immune response,have a certain effect on the treatment of GVHD. This article reviews the research advances on umbilical cord mesenchymal stem cells in hematopoietic stem cell transplantation.