香参软胶囊对小鼠肝癌的抑制作用

Effects of Xiangshen Soft Capsules on Liver Cancer in Mice

目的:研究香参软胶囊对小鼠H22移植性肝癌腹水及其对SMMC7721荷瘤裸鼠的抗肿瘤作用。方法:昆明种小鼠腹腔注射H22肝癌细胞,建立肝癌腹水模型,观察香参软胶囊高(720 mg·kg^(-1))、中(360 mg·kg^(-1))、低(180 mg·kg^(-1))剂量组灌胃给药对H22移植性肝癌腹水小鼠体征及生命延长率的影响;裸鼠右腋窝皮下接种SMMC7721细胞悬液,待瘤块成形后给药,观察香参软胶囊高、中、低剂量组灌胃给药对SMMC7721荷瘤裸鼠肿瘤生长及其瘤重的影响。结果:与H22移植性小鼠肝癌腹水模型组比较,高剂量组显著抑制腹围的增长(P<0.01),延长小鼠生存时间(P<0.01);中剂量组显著延长小鼠生存时间(P<0.05)。与SMMC7721荷瘤裸鼠比较,香参软胶囊各剂量组平均瘤重及肿瘤体积均小于模型组;高剂量组能极显著抑制SMMC7721荷瘤裸鼠肿瘤生长,同时对肿瘤生长的抑制作用略优于平消胶囊组。结论:香参软胶囊显著降低H22肝癌小鼠腹水生成,延长小鼠存活时间;对裸鼠SMMC7721移植性瘤具有明显抑制作用。结果表明香参软胶囊具有较明显的抗肝癌作用。

Objective： To study the anti-tumor effects of Xiangshen soft capsules on H22 tumor-bearing mice and SMMC7721 tumor-bearing nude mice in vivo. Methods： Two different types of transplantation tumor pathologic models were established by subcutaneous injection of hepatocellular carcinoma H22 cells in mice, and SMMC7721 human liver cancer cells in nude mice, respectively. Different doses of Xiangshen soft capsules（720 mg·kg^-1, 360 mg·kg^-1 and 180 mg·kg^-1） were intragastrically administered to tumor-bearing mice. Survival extension and abdominal circumference increasing inhibition were estimated in H22 tumor-bearing mice, and tumor growth and tumor weight were assayed in SMMC7721 human liver cancer cell-bearing nude mice. Results： Compared with the H22 tumor-bearing model mice, abdominal circumference increasing was evidently inhibited with high dose of Xiangshen soft capsules. Life extension was prolonged with both high and medium doses of Xiangshen soft capsules. Compared with the SMMC7721 tumor-bearing model nude mice, tumor volume and weight were decreased with Xiangshen soft capsules. Xiangshen soft capsules at high dose（720 mg·kg^-1） significantly inhibited tumor growth. Conclusion： Xiangshen soft capsules could inhibit liver cancer in mice.