丹红注射液对糖尿病伴高凝状态的疗效观察研究

Effects of Danhong Injection on diabetes associated with hypercoagulable state

目的研究丹红注射液辅助治疗对2型糖尿病(T2DM)伴高凝状态患者血糖、凝血功能、红细胞参数和胰岛功能的影响。方法将94例T2DM伴高凝状态患者随机按1∶1分组,47例行常规降糖治疗者归为对照组,47例在对照组基础上加用丹红注射液者归为联合组,比较两组治疗前后血糖、凝血功能、红细胞参数和胰岛功能变化。结果治疗后,两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)水平均显著降低(P<0.05),凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、血小板表面第四因子(PF4)和可溶性P选择素(CD62P)水平均显著降低(P<0.05),红细胞变形指数显著增高(P<0.05),红细胞聚集指数、红细胞电泳指数、红细胞刚性指数和全血粘度均显著降低(P<0.05),空腹胰岛素(FINS)、胰岛素抵抗指数水平显著降低(P<0.05),C肽和胰岛素分泌指数水平显著升高(P<0.05),且联合组改变幅度均大于对照组(P<0.05)。结论丹红注射液辅助治疗T2DM伴高凝状态,可明显改善患者的血糖水平和高凝状态,恢复血液流变学水平,调节胰岛功能,临床意义显著。

Objective To study the impacts of Danhong Injection on the blood glucose, coagulation function, erythrocyte parameters and islet function in patients with type 2 diabetes mellitus（T2 DM） associated with hypercoagulable state in adjuvant therapy. Methods A total of 94 patients with T2 DM associated with hypercoagulable state were selected and randomly divided into a control group and a combination group in a proportion of 1 ∶1（n =47, respectively）. The control group was treated with conventional hypoglycemic therapy and the combination group was additionally treated with Danhong Injection. The changes in the blood glucose,coagulation function, erythrocyte parameters and islet function before and after the treatment between the two groups were compared.Results After the treatment, the levels of fasting blood-glucose（FPG）, 2 h postprandial blood glucose（2 h PG）, and glycosylated hemoglobin（Hb Alc） decreased significantly（P 〈 0.05）; the prothrombin time（PT）, thrombin time（TT）, activated partial thromboplastin time（APTT）, fibrinogen（Fib）, platelet surface fourth factor（PF4） and soluble p selectin（CD62 P） levels decreased significantly（P 0.05）; the erythrocyte deformation index increased significantly（P 〈 0.05）; the erythrocyte aggregation index, erythrocyte electrophoresis index, erythrocyet index of rigidity and whole blood viscosity decreased significantly（P 〈 0.05）; the FINS and insulin resistance level decreased significantly（P 〈 0.05）, C peptide and insulin secretion index levels increased significantly（P 〈 0.05）, and the changes in the combination group were greater than those in the control group（P 〈 0.05）. Conclusion Danhong Injection can significantly improve the blood glucose level and hypercoagulable state in patients, restore hemorheology level and regulate islet function, and has significant clinical significance in the adjuvant therapy for T2 DM associated with hypercoagulable state.