动态增强磁共振定量分析对布氏杆菌性脊柱炎分期的价值

The value of dynamic contrast-enhanced magnetic resonance imaging in the staging of brucellosis spondylitis

目的应用动态增强磁共振对布氏杆菌性脊柱炎进行定量分析,评估它对布氏杆菌性脊柱炎分期的价值。材料与方法收集有完整生化检验或手术资料的布氏杆菌性脊柱炎患者28例,男性17例,女性11例,平均年龄52岁,行常规磁共振成像及动态增强磁共振检查,在灌注参数图上测量上述疾病患者病变椎体的容积转运参数(K^(trans))、速率常数(K_(ep))、血管外细胞外容积分数(V_e)、血浆容积分数(V_p)值,采用成组t检验比较4者的差异。结果在布氏杆菌性脊柱炎病变组椎体与非病变组椎体的K^(trans)、K_(ep)、V_e、V_p差异均有统计学意义(P<0.05);急性期的病变椎体中,K^(trans)=1.723±0.266,K_(ep)=2.177±0.690;非急性期K^(trans)=2.177±0.690,K_(ep)=1.508±0.877,差异有统计学意义(P<0.05)。结论动态增强磁共振定量分析对布氏杆菌性脊柱炎的诊断和分期具有很高的价值。

Objective： To quantitatively analyze brucellar spondylitis （BS） by applying dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI）, and to evaluate the value of quantitative DCE-MRI in the stating of BS. Materials and methods： Analyzed 28 BS patients with complete biochemical detection or operation data （17 males and 11 females; mean age 52 years old）. All patients received routine MRI and DCE-MRI examinations. Volume transfer constant （Ktrans）, rate constant （Kep）, extravascular extracellular volume fraction （Ve） and plasma volume fraction （Vp） of diseased vertebral bodies of the patients were measured in perfusion parameter maps. The four parameters were compared among the diseased vertebres and the non-diseased vertebres, Ktrans, Kep were compared the acute group and the non-acute group by t-test. Results： Ktrans, Kep, Ve and Vp showed statistically signifcant differences （P〈0.05） between the diseased vertebrae and the non-diseased vertebrae. Ktrans was 1.723±0.266, Kep was 2.177±0.690 in the acute group, Ktrans was 2.177±0.690, Kep was 1.508±0.877 in the non-acute group, it showed statistically signifcant differences （P〈0.05）. Conclusions： DCE-MRI quantitative analysis has great value in the diagnosis and staging of BS.