强化血液灌流对百草枯中毒患者毒素清除及靶器官功能、氧化应激反应的影响

Effects of intensive hemoperfusion on the toxin clearance,target organ function and oxidative stress in patient with paraquat poisoning

目的:探讨强化血液灌流对百草枯中毒患者毒素清除及靶器官功能、氧化应激反应的影响。方法:2013年11月~2017年1月汉川市人民医院收治的百草枯中毒患者56例,回顾治疗方案并分为对照组30例、强化血液灌流组26例。对照组患者接受常规治疗,强化血液灌流组患者接受常规联合强化血液灌流治疗。对比两组百草枯清除效果、靶器官功能、氧化应激反应差异。结果:强化血液灌流组血清中百草枯水平低于对照组,百草枯清除率高于对照组。强化血液灌流组血清中肺纤维化指标PⅠCP、CⅣ、HA的水平低于对照组;血清中肝功能指标ALP、STB、ALT的水平低于对照组;血清中氧化应激指标GSH-Px的水平高于对照组,MDA的水平低于对照组。结论:百草枯中毒患者接受强化血液灌流治疗,可显著提升百草枯清除率并保护重要脏器功能、抑制全身氧化应激反应。

Objective:To study the effects of intensive hemoperfusion on the toxin clearance,target organ function and oxidative stress in patient with paraquat poisoning.Methods:56 patients with paraquat poisoning who were treated in the People's Hospital of Hanchuan between November 2013 and January 2017 were reviewed and divided into the control group(n=30)and the intensive hemoperfusion group(n=26).Control group received conventional therapy,and intensive hemoperfusion group received conventional therapy combined with intensive hemoperfusion.The differences in paraquat clearance effect,target organ function and oxidative stress response were compared between the two groups.Results:Serum paraquat level in intensive hemoperfusion group was lower than that in control group,and the paraquat clearance rate was higher than that of control group.Serum pulmonary fibrosis indexes PⅠCP,CⅣ and HA levels in intensive hemoperfusion group were lower than those in control group;serum liver function indexes ALP,STB and ALT levels were lower than those in control group;serum oxidative stress index GSH-Px level was higher than that in control group whereas MDA level was lower than that in control group.Conclusion:Intensive hemoperfusion can significantly improve the paraquat clearance rate,protect the important organ function and suppress the systemic oxidative stress response in patient with paraquat poisoning.