巴曲酶联合银杏达莫注射液对突发性耳聋患者血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平的影响

Effect of batroxobin combine with ginkgo-damole injection on hemodynamics,coagulation function,fibrinolytic function and related factors in patients with sudden deafness

目的:通过对突发性耳聋患者联合应用巴曲酶和银杏达莫注射液进行治疗,研究联合用药对患者血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平的影响。方法:选取我院治疗的突发性耳聋患者94例,随机分为对照组和观察组,每组47例。所有患者入院后均给予10BU巴曲酶注射液静脉滴注,隔天1次;观察组患者加用30mL银杏达莫注射液静脉滴注,1天1次。检测并比较两组患者治疗前后的血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平。结果:治疗前,两组患者之间的血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平差异无统计学意义(P>0.05);治疗后,对照组患者的WBV、PV水平分别为(5.21±0.58)mPa/s、(1.78±0.32)mPa/s,观察组为(4.13±0.47)mPa/s、(1.31±0.26)mPa/s,与同组治疗前相比,且两组之间差异均具有统计学意义(P<0.05);对照组患者的PT、APTT、TT、PF水平分别为(19.22±3.98)s、(43.57±9.88)s、(15.64±3.27)s、(58.22±10.58)μg/L,观察组为(23.97±4.82)s、(52.49±10.38)s、(20.59±4.15)s、(41.03±8.46)μg/L,与同组治疗前相比,且两组之间差异均具有统计学意义(P<0.05);对照组患者的Fib、D-二聚体、FDP水平分别为(4.52±0.93)g/L、(6.53±1.88)mg/L、(8.17±2.34)μg/ml,观察组为(3.13±0.75)g/L、(9.75±2.14)mg/L、(13.52±2.58)μg/ml,与同组治疗前相比,且两组之间差异均具有统计学意义(P<0.05);对照组患者的血清ET、NO、SOD水平分别为(66.92±5.87)ρg/mL、(48.75±7.61)μmol/L、(95.01±12.38)NU/mL,观察组分别为(63.97±5.24)ρg/mL、(43.11±6.83)μmol/L、(104.79±13.15)NU/mL,与同组治疗前相比,且两组之间差异均具有统计学意义(P<0.05)。结论:对突发性耳聋患者联合应用巴曲酶和银杏达莫注射液进行治疗,可以更加明显地改善患者的血流动力学、凝血功能以及纤维蛋白溶解功能,降低血清ET、NO水平,提高SOD水平,疗效确切,值得临床上推广应用。

Objective:To study the effects of combined use of drugs on hemodynamics,coagulation function,fibrinolytic function and related factors.Methods:Total of 94 patients with sudden deafness in our hospital were selected,which were divided into control group and observation group randomly,with 47 cases in each group.All patients were given 10 BU batroxobin injection intravenous drip after admission every other day;And the patients of observation group were given intravenous drip of 30 mL ginkgo-damole injection,1 times a day.The hemodynamics,coagulation function,fibrinolytic function and related factors were detected and compared between the two groups before and after treatment.Results:Before treatment,there was no statistical difference in hemodynamics,coagulation function,fibrinolytic function and related factors between the two groups(P>0.05);After treatment,the levels of WBV and PV in the control group was(5.21±0.58)mPa/s and(1.78±0.32)mPa/s,and the observation group was(4.13±0.47)mPa/s and(1.31±0.26)mPa/s,compared with the same group before treatment,there were statistical difference(P<0.05),and there was also statistical difference between the two groups(P<0.05);the levels of PT,APTT,TT and PF was(19.22±3.98)s,(43.57±9.88)s,(15.64±3.27)s and(58.22±10.58)μg/L,and the observation group was(23.97±4.82)s,(52.49±10.38)s,(20.59±4.15)s and(41.03±8.46)μg/L,compared with the same group before treatment,there were statistical difference(P<0.05),and there was also statistical difference between the two groups(P<0.05);The levels of Fib,D-dimer and FDP was(4.52±0.93)g/L,(6.53±1.88)mg/L and(8.17±2.34)μg/mL,and the observation group was(3.13±0.75)g/L,(9.75±2.14)mg/L,(13.52±2.58)μg/mL,compared with the same group before treatment,there were statistical difference(P<0.05),and there was also statistical difference between the two groups(P<0.05);The serum levels of ET,NO and SOD was(66.92±5.87)ρg/mL,(48.75±7.61)μmol/L,(95.01±12.38)NU/mL,and the observation group was(63.97±5.24)ρg/mL,(43.11±6.83)μmol/L,(104.79±13.15)NU/mL,compared with the same group before treatment,there were statistical difference(P <0.05),and there was also statistical difference between the two groups(P <0.05).Conclusion The treatment of patients with sudden deafness using batroxobin combine with ginkgo-damole injection,can improve the hemodynamics,coagulation function,fibrinolytic function of patients,decrease the serum levels of ET and NO,improve the levels of SOD,the effect is curative,it's worthy of clinical application.