革兰阳性菌和革兰阴性菌感染患者血清中炎症介质及氧化应激介质含量差异的比较

Comparison of the serum contents of inflammatory mediators and oxidative stress mediators between patients with gram-positive bacteria and gram-negative bacteria infection

目的:比较革兰阳性菌和革兰阴性菌感染患者血清中炎症介质及氧化应激介质含量的差异。方法:选择2015年3月~2017年4月在自贡市第三人民医院诊断为血流细菌感染的患者作为研究对象,根据血培养及菌种鉴定结果分为革兰阳性组和革兰阴性组,测定血清中炎症介质PCT、IL-1β、IL-6、sTREM-1、TNF-α、NGAL、SAA、HPT、hs-CRP及氧化应激介质MDA、AOPP、TAC、CAT、SOD的含量。结果:革兰阴性组患者血清中PCT、IL-1β、IL-6、sTREM-1、TNF-α、NGAL、SAA、HPT、hs-CRP、MDA、AOPP的含量显著高于革兰阳性组,TAC、CAT、SOD的含量显著低于革兰阳性组。结论:革兰阴性菌感染患者血清中炎症介质及氧化应激介质的变化较革兰阳性菌感染患者更为显著。

Objective:To compare the serum contents of inflammatory mediators and oxidative stress mediators between patients with gram-positive bacteria and gram-negative bacteria infection.Methods:Patients who were diagnosed with bloodstream bacterial infection in Zigong Third People's Hospital between March 2015 and April 2017 were selected as the research subjects and divided into gram-positive group and gram-negative group according to the results of blood culture and strain identification,and serum levels of inflammatory mediators PCT,IL-1β,IL-6,sTREM-1,TNF-α,NGAL,SAA,HPT and hs-CRP as well as oxidative stress mediators MDA,AOPP,TAC,CAT and SOD were determined.Results:Serum PCT,IL-1β,IL-6,sTREM-1,TNF-α,NGAL,SAA,HPT,hs-CRP,MDA and AOPP levels of gram-negative group were greatly higher than those of gram-positive group while TAC,CAT and SOD levels were greatly lower than those of gram-positive group.Conclusion:The changes of inflammatory mediators and oxidative stress mediators in the serum of patients with gramnegative bacteria infection are more significant than those of patients with gram-positive bacteria infection.