盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者炎症反应、氧化应激、血管内皮功能及心肌功能的影响

Effect of Trimetazidine Dihydrochloride Tablets adjuvant therapy on inflammatory reaction,oxidative stress,vascular endothelial function and myocardial function in patients with coronary heart disease complicated with heart failure

目的:探讨盐酸曲美他嗪片辅助治疗冠心病伴心力衰竭对患者炎症反应、氧化应激、血管内皮功能及心肌功能指标的影响。方法:98例符合研究筛选标准的冠心病伴心力衰竭患者分为对照组(n=49)和观察组(n=49),对照组给予酒石酸美托洛尔缓释片治疗,观察组给予酒石酸美托洛尔缓释片联合盐酸曲美他嗪片治疗,比较治疗前后两组炎症反应、氧化应激、血管内皮功能及心肌功能指标水平。结果:两组治疗前CRP、TNF-α、MDA、SOD、NO、ET-1、LVEF、LVEDD及LVESD水平数值较为接近,差异比较无统计学意义(P>0.05);与组内治疗前CRP、TNF-α、MDA、ET-1、LVEDD及LVESD水平相比,治疗后两组上是指标水平均显著下降,且观察组治疗后CRP、TNF-α、MDA、ET-1、LVEDD及LVESD水平显著低于治疗后对照组,差异有统计学意义(P<0.05);治疗后的两组SOD、NO、LVEF水平均较治疗前水平显著升高,且观察组水平显著高于对照组,差异有统计学意义(P<0.05)。结论:盐酸曲美他嗪片辅助治疗可有效抑制冠心病伴心力衰竭患者炎性因子释放,改善机体氧化应激状态,对血管内皮功能及心肌功能均具有一定的保护作用,具有重要临床价值。

Objective:To investigate the effects of Trimetazidine Dihydrochloride Tablets on inflammatory reaction,oxidative stress,vascular endothelial function and myocardial function in patients with coronary heart disease complicated with heart failure.Methods:98 patients with coronary heart disease and heart failure who met the criteria of the study were selected as the subjects,based on the random data table they were divided into the control group(n=49)and observation group(n=49),the patients in the control group were treated with Metoprolol Tartrate Sustained-release Tablets treatment,and the patients in the observation group were treated with Metoprolol Tartrate Sustained-release Tablets combined with Trimetazidine Dihydrochloride Tablets,the levels of inflammatory reaction,oxidative stress,vascular endothelial function and myocardial function indexes were compared between the two groups before and after treatment.Results:The difference of the CRP,TNF-α,MDA,SOD,NO,ET-1,LVEF,LVEDD and LVESD levels in the two groups before treatment were not statistically significant(P>0.05);Compared with the levels of the two groups before treatment,the two groups of CRP,TNF-α,MDA,ET-1,LVEDD and LVESD levels after treatment were significantly decreased,and the level of the observation group after treatment was significantly lower than those levels in the control group,the difference was statistically significant(P<0.05);The levels of SOD,NO and LVEF of the two groups after treatment were significantly higher than those in the same group before treatment,and the observation group levels [(88.09±7.51)U/mL,(72.58±14.64)mol/L,(48.34±5.09)% ]were significantly higher than the control group [(79.44±7.27)U/ml,(61.89±11.06)mol/L,(44.19±4.58)%],the difference was statistically significant(P<0.05).Conclusion:Trimetazidine Dihydrochloride Tablets in the treatment of coronary heart disease with heart failure can effectively inhibit the release of inflammatory factors,improve oxidative stress state,vascular endothelial function and myocardial function,has an important clinical value.