冠脉CTA评估冠状动脉斑块性质及其与炎症分子、MMPs/TIMPs的相关性

Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs

目的:研究冠脉CTA对冠状动脉斑块性质的评估价值及其与炎症分子、MMPs/TIMPs的相关性。方法:选择在本院诊断为急性冠脉综合征的患者作为研究的ACS组、诊断为稳定性心绞痛的患者作为研究的SAP组,同期接受体检的健康者作为研究的对照组。采用冠脉CTA检查判断ACS组患者冠状动脉斑块的性质,采集三组受试者血清并测定炎症分子、MMPs/TIMPs胶原代谢分子的含量。结果:ACS组、SAP组患者血清中MIP-1α、MCP-1、sFGL-2、sCD14、CXCL5、I-CTP、III-CTP、EMMPRIN的含量显著高于对照组,TIMP1、TIMP2的含量显著低于对照组;ACS组患者血清中MIP-1α、MCP-1、sFGL-2、sCD14、CXCL5、I-CTP、III-CTP、EMMPRIN的含量显著高于SAP组,TIMP1、TIMP2的含量显著低于SAP组。软斑块、纤维斑块ACS患者血清中MIP-1α、MCP-1、sFGL-2、sCD14、CXCL5、ICTP、III-CTP、EMMPRIN的含量显著高于钙化斑块患者,TIMP1、TIMP2的含量显著低于钙化斑块患者;软斑块ACS患者血清中MIP-1α、MCP-1、sFGL-2、sCD14、CXCL5、I-CTP、III-CTP、EMMPRIN的含量显著高于纤维斑块患者,TIMP1、TIMP2的含量显著低于纤维斑块患者。结论:冠脉CTA对冠状动脉斑块性质的评估与炎症反应及MMPs/TIMPs胶原代谢的改变密切相关。

Objective:To study the evaluation value of coronary CTA for coronary plaque properties and its correlation with inflammatory molecules and MMPs/TIMPs.Methods:Patients who were diagnosed with acute coronary syndrome in Renmin Hospital of Wuhan University between August 2014 and December 2016 were selected as the ACS group of the research,patients who were diagnosed with stable angina pectoris were selected as the SAP group of the research,and healthy subjects who received physical examination during the same period were selected as the control group of the research.Coronary CTA was done to determine the coronary plaque properties of ACS group,and serum was collected from the three groups of subjects to determine the contents of inflammatory molecules and MMPs/TIMPs collagen metabolites.Results:Serum MIP-1α,MCP-1,sFGL-2,sCD14,CXCL5,I-CTP,III-CTP and EMMPRIN contents of ACS group and SAP group were higher than those of control group while TIMP1,TIMP2 contents were lower than those of control group;serum MIP-1α,MCP-1,sFGL-2,sCD14,CXCL5,I-CTP,III-CTP and EMMPRIN contents of ACS group were higher than those of SAP group while TIMP1,TIMP2 contents were lower than those of SAP group.Serum MIP-1α,MCP-1,sFGL-2,sCD14,CXCL5,I-CTP,III-CTP and EMMPRIN contents of ACS patients with soft plaque and fibrous plaque were higher than those of ACS patients with calcified plaque while TIMP1 and TIMP2 contents were lower than those of ACS patients with calcified plaque;serum MIP-1α,MCP-1,sFGL-2,sCD14,CXCL5,I-CTP,III-CTP and EMMPRIN contents of ACS patients with soft plaque were higher than those of ACS patients with fibrous plaque while TIMP1 and TIMP2 contents were lower than those of ACS patients with fibrous plaque.Conclusion:The coronary plaque property evaluation by coronary CTA is closely related to the changes of inflammatory response and MMPs/TIMPs collagen metabolism.