围手术期动脉灌注化疗对可切除性胰腺癌病灶内癌细胞增殖及侵袭活力的影响

Effect of perioperative arterial infusion chemotherapy on the proliferation and invasion of cancer cells in resectable pancreatic cancer lesion

目的:研究围手术期动脉灌注化疗对可切除性胰腺癌病灶内癌细胞增殖及侵袭活力的影响。方法:选择在本院接受胰腺癌根治性手术的患者作为研究对象,随机分为术前接受动脉灌注化疗的灌注化疗组以及术前接受常规干预的常规对照组。手术切除后收集胰腺癌病灶,测定促增殖基因、增殖抑制基因、侵袭基因的mRNA表达量。结果:灌注化疗组患者胰腺癌病灶内Mdig、XIAP、Survivin、USP9X、CyclinD1、MSX2、TPM3、Twist、Snail、Del-1的mRNA表达量均显著低于常规对照组,ARHI、ING4、PTEN、Kail的mRNA表达量均显著高于常规对照组。结论:术前动脉灌注化疗能够降低可切除性胰腺癌病灶内癌细胞的增殖及侵袭活力。

Objective:To study the effect of perioperative arterial infusion chemotherapy on the proliferation and invasion of cancer cells in resectable pancreatic cancer lesion.Methods:Patients who received radical operation for pancreatic cancer in Yidu First People's Hospital between February 2015 and April 2017 were selected as the research subjects and randomly divided into the infusion chemotherapy group who received preoperative arterial infusion chemotherapy and normal control group who received routine preoperative intervention.After surgical resection,the pancreatic cancer lesion was collected to determine the mRNA expression of pro-proliferation genes,anti-proliferation genes and invasion genes.Results:Mdig,XIAP,Survivin,USP9 X,CyclinD1,MSX2,TPM3,Twist,Snail and Del-1 mRNA expression in pancreatic cancer lesions of infusion chemotherapy group were significantly lower than those of normal control group while ARHI,ING4,PTEN and Kail mRNA expression were significantly higher than those of normal control group.Conclusion:Preoperative arterial infusion chemotherapy can reduce the proliferation and invasion of cancer cells in resectable pancreatic cancer lesions.