脑梗死合并肺炎患者微量元素含量、红细胞免疫功能的变化及其与感染指标的关系

The changes of microelement content and erythrocyte immune function in patients with cerebral infarction complicated by pneumonia and their relationship with infection indexes

目的:研究脑梗死合并肺炎患者微量元素含量、红细胞免疫功能的变化及其与感染指标的关系。方法:选择在黄石市中心医院就诊的脑梗死合并肺炎患者作为研究的感染组,另取同期黄石市中心医院收治的脑梗死患者作为研究的对照组。取血清并测定微量元素Zn、Fe、Cu、Se、Ca的含量以及感染指标PCT的含量,取外周血并测定红细胞免疫功能指标。结果:感染组患者血清中PCT的含量显著高于对照组。感染组患者血清中Zn、Fe的含量以及外周血中RBC-ICR、RBC-C3bR、FEER、CD58、CD59的水平显著低于对照组,外周血中FEIR的水平显著高于对照组,Cu、Se、Ca的含量与对照组比较无显著性差异;感染组中PCT高含量患者血清Zn、Fe的含量以及外周血中RBC-ICR、RBC-C3bR、FEER、CD58、CD59的水平显著低于PCT低含量患者,外周血中FEIR的水平显著高于PCT低含量患者,Cu、Se、Ca的含量与PCT低含量患者比较无显著性差异。结论:脑梗死合并肺炎患者体内微量元素Zn、Fe不足以及红细胞免疫功能减弱与感染程度密切相关。

Objective:To study the changes of microelement content and erythrocyte immune function in patients with cerebral infarction complicated by pneumonia and their relationship with infection indexes.Methods:Patients with cerebral infarction complicated by pneumoniain who were treated in Huangshi Central Hospital between April 2014 and February 2017 were selected as the infection group of the research,and patients with cerebral infarction who were treated in Huangshi Central Hospital during the same period were selected as the control group of the research.Serum was collected to determine the contents of trace elements Zn,Fe,Cu,Se and Ca as well as infection index PCT,and peripheral blood was collected to determine the erythrocyte immune function indexes.Results:Serum PCT content of infection group was greatly higher than that of control group.Serum zinc and Fe contents as well as peripheral blood RBC-ICR,RBC-C3 bR,FEER,CD58 and CD59 levels of infection group were greatly lower than those of control group,FEIR level in peripheral blood was obviously higher than that of control group,and Cu,Se and Ca contents were not greatly different from those of control group;serum zinc and Fe contents as well as peripheral blood RBC-ICR,RBC-C3 bR,FEER,CD58 and CD59 levels of infection group of patients with high PCT content were remarkably lower than those of patients with low PCT content,FEIR level in peripheral blood was significantly higher than that of patients with low PCT content,and Cu,Se and Ca contents were not greatly different from those of patients with low PCT content.Conclusion:The deficiency of microelements Zn and Fe as well as the weakening of erythrocyte immune function is closely related to the degree of infection in the patients with cerebral infarction complicated by pneumonia.