摘要
目的:观察α-硫辛酸对2型糖尿病患者骨代谢指标(包括骨形成指标和骨吸收指标)的影响。方法:将50例2型糖尿病老年男性患者,随机分为使用α-硫辛酸组(治疗组)和未使用α-硫辛酸组(对照组),每组各25例。治疗组用α-硫辛酸治疗14d。收集患者用药前基本情况并检测骨形成指标(骨碱性磷酸酯酶、骨钙素、总Ⅰ型胶原氨基端延长肽)和骨吸收指标(β-Ⅰ型胶原羧基端肽降解产物),治疗结束后3个月测定两组患者的骨形成和骨吸收指标的变化并进行统计分析。结果:治疗前治疗组与对照组骨代谢指标无差异;治疗后,治疗组总Ⅰ型胶原氨基端延长肽较治疗前升高(P<0.05),且与对照组比较,差异有统计学意义(P<0.05)。结论:α-硫辛酸可提高2型糖尿病老年男性患者的总Ⅰ型胶原氨基端延长肽,促进骨形成。
Objective:To observe the effects ofα-thioctic acid on bone metabolism in elderly men with type 2 diabetes mellitus.Methods:Totally,50 elderly men with type 2 diabetes mellitus were randomly assigned to theα-thioctic acid group(or the treatment group)and the nonα-thioctic acid group(or the control group),each consisting of 25 patients.The patients in the treatment group were treated withα-thioctic acid for 14 days.General data of the patient conditions were collected before medication.Then,detections were made in bone formation indexes,including bone alkaline phosphatase,osteocalcin,total typeⅠcollagen end amino extended peptide(PINP),and bone resorption index,includingβ-typeⅠcollagen end-carboxy peptide degradation products.Three months after treatment,detection of the changes in the indexes of bone formation and bone resorption was made in the patients of the 2 groups,and statistical analyses were performed accordingly.Results:Before treatment,there were no statistical differences in the indexes of bone metabolism,when comparisons were made between the patients of the 2 groups.However,following treatment,the levels of PINP in the patients of the treatment group elevated,as compared with those before treatment(P〈0.05),and statistical significance could also be noted,when compared with those of the control group(P〈0.05).Conclusion:α-Thioctic acid could elevate PINP level in the elderly men with type 2 diabetes and consequently promote bone formation.
出处
《药学服务与研究》
CAS
2017年第6期415-418,共4页
Pharmaceutical Care and Research
基金
国家自然科学基金青年科学基金项目(81500655)
上海市卫生和计划生育委员会项目(01440050)
上海市科学技术委员会项目(15ZR1437100)
上海市浦东新区卫生系统优秀青年医学人才培养计划(PWRq2014-31)
关键词
Α-硫辛酸
骨质疏松
骨形成
糖尿病
2型
α-thioctic acid
osteoporosis
bone formation
diabetes mellitus
type 2