多中心样本医院成年烧伤患者临床使用抗菌药物分析

Analysis of the antibacterials prescription features of adult burn inpatients in multi-center hospitals

目的:了解全国范围内多中心样本医院成年烧伤患者抗菌药物的临床使用特征,为烧伤治疗的药学服务提供参考。方法:采用频数统计法对多中心样本医院的成年烧伤患者的抗菌药物使用情况进行分析。结果和结论:共12 483例成年烧伤患者纳入统计,患者中中年男性居多。成年烧伤患者抗菌药物使用率为89.65%,抗菌药物使用强度达110.65DDDs,首日抗菌药物使用率为53.75%。我国成年烧伤患者首日抗菌药物使用普遍,头孢菌素类、青霉素类复方制剂、β-内酰胺酶敏感青霉素类为主要的经验性预防用药。烧伤患者抗菌药物联合使用较多,应及时进行病原菌培养,合理应用抗菌药物。

Objective：To investigate the prescription features of anti-bacterials in adult burn inpatients in multi-center hospitals,so as to provide solid evidence for pharmaceutical care in the treatment of burns.Methods：By using frequency statistical method,analyses of antibacterial application in adult burn patients hospitalized in multi-center hospitals were made in the course of the study.Results and Conclusion：Included in the study were 12 483 inpatients,most of whom were medium-aged males.The rate of antibacterial application in adult burn inpatients was 89.65%,antibacterial use density was as high as 110.65 DDDs,and the rate of antibacterial application on the first day of admission was 53.75%.Antibacterial application on the first day of admission in burn inpatients was popular in China,with cephalosporin,penicillin withβ-lactamase inhibitor,orβ-lactamase sensitive penicillin as empirically prophylactic measures.In most cases,combined use of antibiotics were quite common in burn patients,therefore,pathogen culture should duly be performed to ensure rational application of antibiotics.