特应性皮炎患者血清VitD、tIgE、IL-4和IL-6水平检测及临床意义

Detection of serum VitD,tIgE,IL-4 and IL-6 levels in patients with atopic dermatitis and its clinical significance

目的分析患者血清维生素D(VitD)、总免疫球蛋白E(tIgE)、白细胞介素-4(IL-4)及IL-6水平检测在评价特应性皮炎中的临床意义。方法随机选取2015年1月至2016年1月于该院就诊的特应性皮炎患者43例作为观察组,另选取同期健康体检者43例作为对照组,比较两组研究对象血清VitD、tIgE、IL-4和IL-6水平。结果观察组tIgE、IL-4和IL-6水平明显高于对照组,差异有统计学意义(P<0.05),血清VitD明显低于对照组,差异也有统计学意义(P<0.05);观察组中VitD缺乏患者的tIgE、IL-4和IL-6水平明显高于VitD不足和VitD充足的患者,差异均有统计学意义(P<0.05),但VitD不足和VitD充足患者tIgE、IL-4和IL-6水平比较差异无统计学意义(P>0.05);对照组中VitD缺乏者tIgE水平明显高于VitD不足和VitD充足者,差异有统计学意义(P<0.05),且VitD充足者tIgE水平明显高于VitD不足者,差异有统计学意义(P<0.05),但VitD缺乏者、VitD不足者及VitD充足者IL-4和IL-6水平两两比较差异无统计学意义(P>0.05)。VitD水平与患者病情呈负相关(r=-0.572,P<0.05),tIgE、IL-4与患者病情呈正相关(r=0.546、0.586,P<0.05),IL-6与患者病情无相关性(r=0.151,P>0.05)。结论特应性皮炎患者的病情严重程度与血清VitD、tIgE、IL-4水平有关,对患者血清VitD、tIgE、IL-4和IL-6水平进行检测,能够为特应性皮炎的临床诊断及治疗提供参考依据。

Objective To study the clinical significance of the detection of serum VitD,tIgE,IL-4 and IL-6 in patients with atopic dermatitis.Methods From January 2015-2016 and January in the hospital,43 cases of the patients with atopic dermatitis were randomly selected as the observation group,and 43 healthy cases were randomly selected as the control group.Serum VitD,tIgE,IL-4 and IL-6 levels of two groups were compared.Results The levels of tIgE,IL-4 and IL-6 in the observation group were significantly higher than those in the control group(P<0.05),but serum VitD in observation group was significantly lower than the control group(P<0.05);in the observation group,the levels of tIgE,IL-4 and IL-6 in patients lacking in VitD was significantly higher than those in patients with sufficient VitD or with insufficient VitD,and the difference was statistically significant(P<0.05),but the difference between the levels of tIgE,IL-4 and IL-6 in patients with sufficient VitD and with insufficient VitD was not statistically significant(P>0.05);In the control group,the level of tIgE in patients lacking in VitD was significantly higher than that in patients with sufficient VitD and with insufficient VitD,and the difference was statistically significant(P<0.05).The level of tIgE in patients with sufficient VitD was significantly higher than that in patients with insufficient VitD,and the difference was statistically significant(P<0.05).But the differences of levels of IL-4 an IL-6 between the patients lacking in VitD and the patients with sufficient VitD and the patients with insufficient VitD were not statistically significant(P>0.05).VitD was negatively correlated with the patient′s condition(r=-0.572,P<0.05),the levels of IL-4 and tIgE were positively correlated with the patient′s condition(r=0.546,0.586;P<0.05),and IL-6 had no correlation with the patient′s condition(r=0.151,P>0.05).Conclusion The severity of atopic dermatitis is related to the levels of serum VitD,tIgE,IL-4 and IL-6.So the detection of serum VitD,tIgE,IL-4 and IL-6 could provide reference for the clinical diagnosis and treatment decision of atopic dermatitis.