3项指标在慢性阻塞性肺疾病检测中的临床意义

Clinical significance of plasma D-two,fibrinogen and fibrinogen degradation products in the detection of chronic obstructive pulmonary disease

目的观察血浆D-二聚体(D-D)、纤维蛋白原(FIB)及纤维蛋白(原)降解产物(FDP)在慢性阻塞性肺疾病(COPD)检测中的临床意义。方法随机选择2015年1月至2016年12月在重庆市江津区第二人民医院进行治疗的COPD患者100例作为观察组,另选择同期100例健康体检者作为对照组,对两组研究对象均进行D-D、FIB、FDP水平检测,比较观察组与对照组上述指标水平,比较COPD急性发作期与稳定期患者D-D、FIB、FDP水平的差异。结果观察组患者D-D、FIB、FDP水平分别为(2.41±1.09)mg/L、(5.22±1.48)g/L、(7.04±3.22)mg/L,明显高于对照组的(0.33±0.22)mg/L、(3.19±0.73)g/L、(4.18±1.37)mg/L,差异均有统计学意义(P<0.05);COPD急性发作期患者D-D、FIB、FDP水平分别为(3.27±1.66)mg/L、(6.16±2.03)g/L、(7.62±3.20)mg/L,明显高于COPD稳定期患者的(0.92±0.27)mg/L、(3.49±0.76)g/L、(4.53±1.08)mg/L,差异均有统计学意义(P<0.05)。结论 D-D、FIB、FDP水平能够反映COPD患者病情的变化情况,可以作为COPD患者治疗方案的确定和疗效评估依据。

Objective To investigate the clinical significance of plasma D-two(D-D),fibrinogen(FIB)and fibrinogen degradation products(FDP)in the detection of chronic obstructive pulmonary disease(COPD).Methods 100 COPD patients,received treatment from January 2015 to December 2016 in the hospital,were randomly selected as the observation group,and 100 healthy cases with physical examination in the hospital at the same period time were select as control group.The patients in two groups were given DD,FIB,FDP level tests,the results were compared between two groups,and the differences in levels of patients with stable phase and with the acute phase were compared.Results The D-D,FIB,FDP levels of patients in observation group were(2.41±1.09)mg/L,(5.22±1.48)g/L,(7.04±3.22)mg/L,were significantly higher than those in the control group that were(0.33±0.22)mg/L,(3.19±0.73)g/L,(4.18±1.37)mg/L,and there was a statistically significant difference(P<0.05);the D-D,FIB,FDP levels of patients with acute exacerbation of COPD were(3.27±1.66)mg/L,(6.16±2.03)g/L,(7.62±3.20)mg/L,and were significantly higher than those in the control group that were(0.92±0.27)mg/L,(3.49±0.76)g/L and(4.53±1.08)mg/L,and has a statistically significant difference(P<0.05).Conclusion The levels of D-D,FIB and FDP can reflect the changes of COPD patients′condition,and can be used as the basis for the treatment of COPD patients and the evaluation of the curative effect.