摘要
目的观察TNFAIP3基因在结外鼻型NK/T细胞淋巴瘤中的异常,并评估其预后价值。方法利用联合免疫荧光和荧光原位杂交(fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasm,FICTION)法检测109例结外鼻型NK/T细胞淋巴瘤中TNFAIP3基因的表达。结果在检测成功的78例结外鼻型NK/T细胞淋巴瘤中发现32.1%(25/78)病例存在TNFAIP3基因缺失。TNFAIP3基因缺失与患者性别、年龄、B症状、肿瘤分期、乳酸脱氢酶水平无明显相关性(P均>0.05),与国际预后指数(international prognostic index,IPI)有关(P=0.019)。结论结外鼻型NK/T细胞淋巴瘤中存在的高比例TNFAIP3缺失,且与IPI关联,提示TNFAIP3缺失具有重要的预后价值。
Purpose To explore the prognostic value of de- letion of the TNFAIP3 genc in natural killer/T-cell lymphoma, nasal type detected with fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasm （FICTION）. Methods FICTION was performed to detect the abnormalities of TNFAIP3 gene in 109 cases of natural killer/T- cell lymphoma, nasal type. Results TNFAIP3 deletion was found in 25/79 detectable cases. The deletion of TNFAIP3 waspositively correlated with the International Prognosis Index （lPl） （P =0. 019）. Conclusion Frequent deletion of TNFAIP3 was associated with IP1 in natural killer/T-cell lymphoma, nasal type, suggesting the important prognostic value of TNFAIP3 in the natural killer/T-cell lymphoma, nasal type.
出处
《临床与实验病理学杂志》
CSCD
北大核心
2017年第12期1307-1310,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
国家自然科学基金(81570176)
