摘要
目的探讨甲状腺乳头状癌(papillary thyroid carcinoma,PTC)组织中DOG-1和C-erb B-2的表达及临床意义。方法采用免疫组化SP法检测48例PTC和30例甲状腺良性病变(结节性甲状腺肿15例、桥本甲状腺炎15例)中DOG-1和C-erb B-2蛋白的表达。结果 PTC中DOG-1的阳性率(27.08%,13/48)明显高于甲状腺良性病变(0,0/30),两者差异有显著性(P<0.05)。C-erb B-2的阳性率(39.58%,19/48)也明显高于甲状腺良性病变(3.33%,1/30),两者差异有显著性(P<0.05)。DOG-1、C-erb B-2的表达均与患者临床分期、淋巴结转移明显相关;在多灶且有淋巴结转移病例中DOG-1与C-erb B-2的表达呈显著正相关(r=0.503,P=0.024)。结论 DOG-1及C-erb B-2的表达与PTC的转化、进展密切相关,联合检测可以作为判断PTC的生物学行为、评估其复发风险的重要指标,并为靶向治疗提供可能性。
Purpose To investigate the expression and clinical significance of DOG-1 and C-erbB-2 in papillary thyroid carcinoma. Methods Immunohistochemical SP method was used to detect the expression of DOG-1 and C-erbB-2 protein in 48 cases of papillary thyroid carcinoma and 30 cases of benign thyroid lesions （ 15 cases of nodular goiter and 15 cases of Hash- imoto＇ s thyroiditis）. Results The DOG-1 positive rate of thy- roid papillary carcinoma （ 27.08% , 13/48 ） was significantly higher than that of benign lesions （0, 0/30） , the difference was significant （ P 〈 0. 05 ）. The C-erbB-2 positive rate （ 39. 58% , 19/48 ） was significantly higher than that of benign lesions （3.33% , 1/30） , the difference was significant （ P 〈 0.05 ）.Positive expression of DOG-1 as well as C-erbB-2 correlated with advanced TNM and presence of lymph node metastasis. The ex- pression of DOG-1 and C-erbB-2 in patients with multifocal car- cinomas combined with lymphatic metastasis showed a significant positive correlation （ r = 0. 503, P = 0. 024 ）. Conclusion The data suggest that DOG-1 and C-erbB-2 contribute to the patho- genesis and progress of thyroid papillary carcinoma. Our results introduce DOG-1 combined with C-erbB-2 as a promising bio- marker for recurrence prediction and target therapy.
出处
《临床与实验病理学杂志》
CSCD
北大核心
2017年第12期1360-1363,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
江苏省自然科学基金(BK20161107)
