苦木茎的化学成分

Chemical constituents from the stems of Picrasma quassioides Bennet

采用硅胶、ODS和凝胶等柱色谱方法对苦木(Picrasma quassioides Bennet)干燥茎的化学成分进行分离纯化,通过NMR、MS等波谱技术鉴定了17个化合物,包括6个β-咔巴啉类生物碱:1-methoxycarbonyl-β-carboline(1),1-carbamoyl-β-carbolin(2),4-methoxy-β-carboline-1-carboxylic acid methyl ester(3),1-ethoxycarbonyl-β-carboline(4),1-ethyl-β-carboline(5),cordysinin C(6),5个铁屎米-6-酮类生物碱:4,5-dimethoxycanthin-6-one(7),11-hydroxycanthin-6-one(8),5-hydroxycanthin-6-one(9),5-hydroxy-4-methoxycanthin-6-one(10),canthin-6-one(11);2个铁屎米-5,6-二酮类生物碱:3-methyl-4-methyoxycanthin-5,6-dione(12),3-methylcanthin-5,6-dione(13);3个倍半萜类化合物:10α-hydroxycadin-4-en-al(14),canangaterpenes III(15),15-oxo-T-cadinol(16),1个甾体类化合物androsta-1,4-diene-3,17-dione(17)。其中化合物16为新的天然产物,化合物5、6和14~17为首次从苦木中分离鉴定。

The phytochemical studies on the stems of Picrasma quassioides Bennet led to the isolation of seven β-carboline alkaloids（1-6）,five cantin-6-one alkaloids（7-11）,two canthin-5,6-dione（12,13）,three sesquiterpenes（14-16）,and one steroids（17）.Their structures were elucidated by the combination of spectroscopic analyses（ESI-MS,1 H NMR and13 C NMR） and the comparisons with the reference.Compound 16 is a new natural product,and this is the first report for compounds 5,6,14-17 from the species P.quassioides.