红细胞分布宽度与2型糖尿病肾病的相关性研究

The Relation between Red Blood Cell Distribution Width and Diabetic Kidney Disease

目的探讨2型糖尿病患者红细胞分布宽度(RDW)与2型糖尿病肾病(DKD)的相关性。方法回顾性收集2010年1月~2015年1月住院的2型糖尿病伴增生性视网膜病变的患者资料,检测患者实验指标,采用Logistic回归分析确定DKD的危险因素。结果共入组772名Ⅱ型糖尿病患者,其中DKD 502例(65.0%),多因素Logistic回归分析表明,红细胞分布宽度(RDW)[比值比(OR)值为1.82,95%可信区间(CI)为1.16~2.43,P=0.008]、舒张压(DBP)(OR值为1.12,95%CI为1.04~1.15,P=0.010)、红细胞沉降率(ESR)(OR值为1.05,95%CI为1.02~1.06,P=0.025)是DKD的独立危险因素。结论 RDW是Ⅱ型DKD伴增生性视网膜病变的独立危险因素;DBP和ESR也与DKD的发生风险密切相关。

Objective To explore the relation between red blood cell distribution width and diabetic kidney disease.Methods Data was retrospectively collected from patients with type II diabetes with proliferative retinopathy between January 2010 and January 2015.Logistic regressionwas used for multivariate analysis of factors associated with diabetic kidney diseasea-esults Among 772 pa- tients,502 （65%） of the participants had diabetic kidney disease.Logistic regression indicated that RDW[odds ratio （OR） 1.82,95% confidence interval（CI）l.16-2.43,P=0.008],diastolic blood pressure （OR 1.12,95%CI 1.04-l.15,P=0.010）and erythrocyte sedimentation rate （OR 1.05,95%CI 1.02-1.06,P=0.025） were independently associated with diabetic kidney disease.Conclusion RDW was an independent risk factors for diabetic kidney disease. DBP and ESR are closely related to the risk of diabetic kidney disease.