冷冻电子显微学——2017年度诺贝尔化学奖成果简析

Cryo-clectron microscopy: Commentary on the 2017 Nobel Prize in Chemistry

2017年诺贝尔化学奖授予Jacques Dubochet,Joachim Frank和Richard Henderson 3位科学家,以表彰他们在发展利用冷冻电子显微学技术解析溶液中生物大分子高分辨率结构方面做出的开创性贡献。本文评述冷冻电子显微学的发展历程、生物大分子三维重构技术的发展、最近导致冷冻电子显微学迅速崛起的技术突破以及该技术未来的发展趋势。

The 2017 Nobel Prize for Chemistry was awarded to three scientists （Jacques Dubochet, Joachim Frank and Richard Henderson） for developing cryo-electron microscopy for high-resolution structure determination of biomolecules in solutions. This commentary describes the development of cryo-electron microscopy, three-dimensional reconstruction of macromolecules, major technology breakthroughs leading to the recent uprising of cryo-electron microscopy, and the future perspective of the field.