Wnt信号通路上关键基因在哈萨克族食管癌中的表达

Key Genes Expression of Wnt Signaling Pathway in Kazak in Esophageal Cancer

目的:探讨Wnt信号通路上关键基因CK2和SFRP2在哈萨克族食管癌中的表达意义。方法:选取2007~2014年经手术病理证实为哈萨克族原发性食管鳞癌患者75例,癌旁组织75例。采用免疫组化方法检测食管鳞癌及癌旁组织中CK2、SFRP2的蛋白表达,结合患者临床资料,获得相关病理参数,应用统计学方法,探讨二者在Wnt信号通路上的相互作用及与其他临床资料的关系。结果:(1)食管鳞癌组织中CK2高表达、SFRP2低表达,癌旁组织中SFRP2高表达、CK2低表达(P<0.05),临床病理参数方面CK2的表达与肿瘤浸润深度相关(P<0.05),与其他临床病理参数无关。SFRP2表达与民族、年龄、性别、肿瘤部位、肿瘤大小、淋巴结转移、血管神经侵犯不相关(P﹥0.05)。CK2和SFRP2在哈萨克族食管鳞癌组织中的表达呈负相关(P<0.05)。结论:CK2、SFRP2在Wnt信号通路上可能参与食管癌的发生、发展;CK2、SFRP2可能是治疗食管癌的潜在分子靶点。

Objective： To study expression CK2 ,SFRP2 that were key genes of Wnt signaling pathway in kazak in esophageal cancer. Methods ：From 2007 to 2014 in pathologically confirmed primary esophageal squamous cell carcinoma in 75 kazak cases, 75 cases of adjacent tissue . CK2 ,SFRP2 were detected by immunohistochemical method in esophageal squamous cell carcinoma and adjacent tissue. And collect the clinical data of 75 patients, To obtain relevant pathological parameters, the application of statistical methods to explore the relationship between CK2,SFRP2 and other clinical data. Results： （ 1 ） The high expression of CK2 in esophageal carcinoma, The low expression of SFRP2 in esophageal cancer tis- sues , The low expression of CK2 in esophageal carcinoma adjacent tissue, The high expression of SFRP2 in esophageal cancer tissues adjacent tissue（ P 〈 0.05 ）, CK2 was associated with invasion depth （ P 〈 0.05 ） . CK2 was not associated with other clinical parameters（ P 〉 0.05 ）, the expression of SFRP2 was not associated the nationality, age, gender,tumor location, tumor size, lymph node metastasis, degree of differentiation, depth of invasion, vascular nerve invasion pa- rameter （P 〉0.05） CK2 is negatively related to SFRP2（P 〈0.05） . Conclusion： CK2,SFRP2 in Writ pathways may ad- just the occurrence and development of esophageal cancer, which may be a potential molecular target for the treatment of e- sophageal cancer.